Cargando…

Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles

Recently, the development of effective strategies for enhancing drug delivery to the brain has been a topic of great interest in both clinical and pharmaceutical fields. In this review, we summarize our studies evaluating nose-to-brain delivery of drugs and small interfering ribonucleic acids in com...

Descripción completa

Detalles Bibliográficos
Autor principal:	Kanazawa, Takanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4294762/ https://www.ncbi.nlm.nih.gov/pubmed/25610007 http://dx.doi.org/10.2147/MDER.S70856

Ejemplares similares

In vitro evaluation of endothelial exosomes as carriers for small interfering ribonucleic acid delivery
por: Banizs, Anna B, et al.
Publicado: (2014)

Superiority of TPGS-loaded micelles in the brain delivery of vinpocetine via administration of thermosensitive intranasal gel
por: Ahmed, Tarek A, et al.
Publicado: (2019)

Small Interfering Ribonucleic Acid as Lipid-Lowering Therapy: Inclisiran in Focus
por: Rakocevic, Jelena, et al.
Publicado: (2023)

Interfering ribonucleic acids that suppress expression of multiple unrelated genes
por: Passioura, Toby, et al.
Publicado: (2009)

Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation
por: Rodriguez, Myosotys, et al.
Publicado: (2017)

Intranasal Delivery of Camptothecin-Loaded Tat-Modified Nanomicells for Treatment of Intracranial Brain Tumors
por: Taki, Hiroyuki, et al.
Publicado: (2012)

High-throughput screening of small interfering ribonucleic acid identifies important modulators in islet dysfunction and apoptosis
por: Nemoto, Masami, et al.
Publicado: (2015)

Anti-Metastatic Effects on Melanoma via Intravenous Administration of Anti-NF-κB siRNA Complexed with Functional Peptide-Modified Nano-Micelles
por: Ibaraki, Hisako, et al.
Publicado: (2020)

Author Correction: Intranasal drug delivery of small interfering RNA targeting Beclin1 encapsulated with polyethylenimine (PEI) in mouse brain to achieve HIV attenuation
por: Rodriguez, Myosotys, et al.
Publicado: (2018)

Clozapine-Encapsulated Binary Mixed Micelles in Thermosensitive Sol–Gels for Intranasal Administration
por: Tan, Madeleine S. A., et al.
Publicado: (2022)

Plasma Pharmacokinetics of N-Acetylgalactosamine-Conjugated Small-Interfering Ribonucleic Acids (GalNAc-Conjugated siRNAs)
por: Sten, Sebastian, et al.
Publicado: (2023)

Delivery of Short Interfering Ribonucleic Acid-Complexed Magnetic Nanoparticles in an Oscillating Field Occurs via Caveolae-Mediated Endocytosis
por: Lim, Jenson, et al.
Publicado: (2012)

Utilization of Polymeric Micelles as a Lucrative Platform for Efficient Brain Deposition of Olanzapine as an Antischizophrenic Drug via Intranasal Delivery
por: Abo El-Enin, Hadel A., et al.
Publicado: (2022)

Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain
por: Liu, Shanshan, et al.
Publicado: (2018)

Utility of a Novel Micro-Spraying Device for Intranasal Administration of Drug Solutions to Mice
por: Suzuki, Naoto, et al.
Publicado: (2023)

Advances in Biodegradable Nano-Sized Polymer-Based Ocular Drug Delivery
por: Lynch, Courtney, et al.
Publicado: (2019)

Investigation of the Transport Pathways Associated with Enhanced Brain Delivery of Peptide Drugs by Intranasal Coadministration with Penetratin
por: Kamei, Noriyasu, et al.
Publicado: (2021)

Advantages and Disadvantages of Inclisiran: A Small Interfering Ribonucleic Acid Molecule Targeting PCSK9—A Narrative Review
por: Merćep, Iveta, et al.
Publicado: (2022)

Quality by Design Based Formulation Study of Meloxicam-Loaded Polymeric Micelles for Intranasal Administration
por: Sipos, Bence, et al.
Publicado: (2020)

Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles
por: Kanazawa, Takanori, et al.
Publicado: (2019)

Perivascular and Perineural Pathways Involved in Brain Delivery and Distribution of Drugs after Intranasal Administration
por: Lochhead, Jeffrey J., et al.
Publicado: (2019)

Intranasal Administration of N-acetyl-L-cysteine Combined with Cell-Penetrating Peptide-Modified Polymer Nanomicelles as a Potential Therapeutic Approach for Amyotrophic Lateral Sclerosis
por: Kurano, Takumi, et al.
Publicado: (2022)

Evaluating the Efficacy of a Small Interfering Ribonucleic Acid Molecule, Givosiran, in Treating Acute Intermittent Porphyria: A Systematic Review
por: Patel, Priyansh, et al.
Publicado: (2023)

Recent Studies and Progress in the Intratumoral Administration of Nano-Sized Drug Delivery Systems
por: Yun, Wan Su, et al.
Publicado: (2023)

mPEG-PLA/TPGS mixed micelles via intranasal administration improved the bioavailability of lamotrigine in the hippocampus
por: Yu, Anan, et al.
Publicado: (2017)

Synthesis and Characterization of Fatty Acid Grafted Chitosan Polymeric Micelles for Improved Gene Delivery of VGF to the Brain through Intranasal Route
por: Lamptey, Richard Nii Lante, et al.
Publicado: (2022)

Advances in the Design of (Nano)Formulations for Delivery of Antisense Oligonucleotides and Small Interfering RNA: Focus on the Central Nervous System
por: Mendonça, Monique C. P., et al.
Publicado: (2021)

In vitro study of the effect of small interfering ribonucleic acid on the expression of FOXN1 and B cell-attracting chemokine 1 in thymoma cell lines
por: Zhang, Hui, et al.
Publicado: (2015)

The Intersection of Genome-Wide Association Studies and High-Throughput Small Interfering Ribonucleic Acid Screens Allows for the Identification of Novel Pathways Relevant to Atherosclerosis
por: Nanda, Vivek, et al.
Publicado: (2017)

Role of mucoadhesive polymers in enhancing delivery of nimodipine microemulsion to brain via intranasal route
por: Pathak, Rudree, et al.
Publicado: (2014)

Correction: Therapeutic Effects in a Transient Middle Cerebral Artery Occlusion Rat Model by Nose-To-Brain Delivery of Anti-TNF-Alpha siRNA with Cell-Penetrating Peptide-Modified Polymer Micelles. Pharmaceutics, 2019, 11(9), 478
por: Kanazawa, Takanori, et al.
Publicado: (2019)

Self-assembly of cholesterol end-capped polymer micelles for controlled drug delivery
por: Gao, Ming, et al.
Publicado: (2020)

Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients
por: Jin, Zhiyu, et al.
Publicado: (2022)

Inhibition of connective tissue growth factor by small interfering ribonucleic acid prevents increase in extracellular matrix molecules in a rodent model of diabetic retinopathy
por: Winkler, Jennifer L., et al.
Publicado: (2012)

Novel Intranasal Drug Delivery: Geraniol Charged Polymeric Mixed Micelles for Targeting Cerebral Insult as a Result of Ischaemia/Reperfusion
por: M. Soliman, Sara, et al.
Publicado: (2020)

Effect of Hydration in Corona Layer on Structural Change of Thermo-Responsive Polymer Micelles
por: Akino, Yusuke, et al.
Publicado: (2019)

Shortcut Approaches to Substance Delivery into the Brain Based on Intranasal Administration Using Nanodelivery Strategies for Insulin
por: Tashima, Toshihiko
Publicado: (2020)

Role of Polymer Micelles in the Delivery of Photodynamic Therapy Agent to Liposomes and Cells
por: Gibot, Laure, et al.
Publicado: (2020)

Safety and Tolerability Study of an Intravenously Administered Small Interfering Ribonucleic Acid (siRNA) Post On-Pump Cardiothoracic Surgery in Patients at Risk of Acute Kidney Injury
por: Demirjian, Segav, et al.
Publicado: (2017)

Synthesis and in vitro experiments of carcinoma vascular endothelial targeting polymeric nano-micelles combining small particle size and supermagnetic sensitivity
por: Zhang, Yi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_aebb6g10fisb7d8ee6bq6s52kj