Cargando…
Protective and dysregulated T cell immunity in RSV infection()
Respiratory syncytial virus (RSV) is the most important cause of infantile bronchiolitis and a major pathogen in elderly and immunosuppressed persons. Although RSV shows limited antigenic diversity, repeated infections occur throughout life. Vaccine development has been delayed by poor immunogenicit...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295022/ https://www.ncbi.nlm.nih.gov/pubmed/23806514 http://dx.doi.org/10.1016/j.coviro.2013.05.005 |
_version_ | 1782352775927037952 |
---|---|
author | Openshaw, Peter J Chiu, Christopher |
author_facet | Openshaw, Peter J Chiu, Christopher |
author_sort | Openshaw, Peter J |
collection | PubMed |
description | Respiratory syncytial virus (RSV) is the most important cause of infantile bronchiolitis and a major pathogen in elderly and immunosuppressed persons. Although RSV shows limited antigenic diversity, repeated infections occur throughout life. Vaccine development has been delayed by poor immunogenicity, production issues and the fear of causing enhanced disease. T cells assist in viral clearance, but immune regulation serves to limit these responses and to prevent the exaggerated inflammatory response to RSV infection seen in children with bronchiolitis. Severe RSV disease can therefore be regarded as a dysregulated response to an otherwise trivial infection. Further insights into the role of T cells (including Th17) are needed to enable the rational design of safe, effective vaccines and novel treatments. |
format | Online Article Text |
id | pubmed-4295022 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-42950222015-01-21 Protective and dysregulated T cell immunity in RSV infection() Openshaw, Peter J Chiu, Christopher Curr Opin Virol Article Respiratory syncytial virus (RSV) is the most important cause of infantile bronchiolitis and a major pathogen in elderly and immunosuppressed persons. Although RSV shows limited antigenic diversity, repeated infections occur throughout life. Vaccine development has been delayed by poor immunogenicity, production issues and the fear of causing enhanced disease. T cells assist in viral clearance, but immune regulation serves to limit these responses and to prevent the exaggerated inflammatory response to RSV infection seen in children with bronchiolitis. Severe RSV disease can therefore be regarded as a dysregulated response to an otherwise trivial infection. Further insights into the role of T cells (including Th17) are needed to enable the rational design of safe, effective vaccines and novel treatments. Elsevier 2013-08 /pmc/articles/PMC4295022/ /pubmed/23806514 http://dx.doi.org/10.1016/j.coviro.2013.05.005 Text en © 2013 The Authors https://creativecommons.org/licenses/by-nc-sa/3.0/ Open Access under CC BY-NC-SA 3.0 (https://creativecommons.org/licenses/by-nc-sa/3.0/) license |
spellingShingle | Article Openshaw, Peter J Chiu, Christopher Protective and dysregulated T cell immunity in RSV infection() |
title | Protective and dysregulated T cell immunity in RSV infection() |
title_full | Protective and dysregulated T cell immunity in RSV infection() |
title_fullStr | Protective and dysregulated T cell immunity in RSV infection() |
title_full_unstemmed | Protective and dysregulated T cell immunity in RSV infection() |
title_short | Protective and dysregulated T cell immunity in RSV infection() |
title_sort | protective and dysregulated t cell immunity in rsv infection() |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295022/ https://www.ncbi.nlm.nih.gov/pubmed/23806514 http://dx.doi.org/10.1016/j.coviro.2013.05.005 |
work_keys_str_mv | AT openshawpeterj protectiveanddysregulatedtcellimmunityinrsvinfection AT chiuchristopher protectiveanddysregulatedtcellimmunityinrsvinfection |