Valproic Acid-induced Hyperammonemic Encephalopathy Promoted by Levetiracetam

Encephalopathy resulting from the administration of levetiracetam (LEV) is a rare occurrence. We experienced a patient receiving LEV treated with valproic acid (VPA) for partial seizures with secondary generalization, following which she developed hyperammonemic encephalopathy and showed complete re...

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Detalles Bibliográficos
Autores principales: Roh, Sook Young, Jang, Hyun-soon, Jeong, Eun Hye, Kim, Byung-Su, Sunwoo, Moon Kyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Epilepsy Society 2014
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295059/
https://www.ncbi.nlm.nih.gov/pubmed/25625094
http://dx.doi.org/10.14581/jer.14017
Descripción
Sumario:Encephalopathy resulting from the administration of levetiracetam (LEV) is a rare occurrence. We experienced a patient receiving LEV treated with valproic acid (VPA) for partial seizures with secondary generalization, following which she developed hyperammonemic encephalopathy and showed complete recovery after the drug was withdrawan. LEV is able to promote hyperammonemic encephalopathy when added to VPA.

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