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The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer
Other than being present at the surface of red blood cells, the antigens of the ABO blood group system are efficiently expressed by a variety of human cells and tissues. Several studies recently described the involvement of the ABO blood group in the pathogenesis of many human disorders, including c...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295232/ https://www.ncbi.nlm.nih.gov/pubmed/25592962 http://dx.doi.org/10.1186/s12916-014-0250-y |
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author | Franchini, Massimo Lippi, Giuseppe |
author_facet | Franchini, Massimo Lippi, Giuseppe |
author_sort | Franchini, Massimo |
collection | PubMed |
description | Other than being present at the surface of red blood cells, the antigens of the ABO blood group system are efficiently expressed by a variety of human cells and tissues. Several studies recently described the involvement of the ABO blood group in the pathogenesis of many human disorders, including cardiovascular disease and cancer, so that its clinical significance extends now beyond the traditional boundaries of transfusion medicine. In a large cohort study recently published in BMC Medicine and including over 50,000 subjects, Etemadi and colleagues reported that nearly 6% of total deaths and as many as 9% of cardiovascular deaths could be attributed to having non-O blood groups, a condition that was also found to be associated with increased risk of gastric cancer. In this commentary, the clinical implications of ABO blood groups are critically discussed and a possible common pathogenic mechanism involving the von Willebrand factor is described. Please see related article http://dx.doi.org/10.1186/s12916-014-0237-8. |
format | Online Article Text |
id | pubmed-4295232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-42952322015-01-16 The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer Franchini, Massimo Lippi, Giuseppe BMC Med Commentary Other than being present at the surface of red blood cells, the antigens of the ABO blood group system are efficiently expressed by a variety of human cells and tissues. Several studies recently described the involvement of the ABO blood group in the pathogenesis of many human disorders, including cardiovascular disease and cancer, so that its clinical significance extends now beyond the traditional boundaries of transfusion medicine. In a large cohort study recently published in BMC Medicine and including over 50,000 subjects, Etemadi and colleagues reported that nearly 6% of total deaths and as many as 9% of cardiovascular deaths could be attributed to having non-O blood groups, a condition that was also found to be associated with increased risk of gastric cancer. In this commentary, the clinical implications of ABO blood groups are critically discussed and a possible common pathogenic mechanism involving the von Willebrand factor is described. Please see related article http://dx.doi.org/10.1186/s12916-014-0237-8. BioMed Central 2015-01-16 /pmc/articles/PMC4295232/ /pubmed/25592962 http://dx.doi.org/10.1186/s12916-014-0250-y Text en © Franchini and Lippi; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Commentary Franchini, Massimo Lippi, Giuseppe The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer |
title | The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer |
title_full | The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer |
title_fullStr | The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer |
title_full_unstemmed | The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer |
title_short | The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer |
title_sort | intriguing relationship between the abo blood group, cardiovascular disease, and cancer |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295232/ https://www.ncbi.nlm.nih.gov/pubmed/25592962 http://dx.doi.org/10.1186/s12916-014-0250-y |
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