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The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer

Other than being present at the surface of red blood cells, the antigens of the ABO blood group system are efficiently expressed by a variety of human cells and tissues. Several studies recently described the involvement of the ABO blood group in the pathogenesis of many human disorders, including c...

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Autores principales: Franchini, Massimo, Lippi, Giuseppe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295232/
https://www.ncbi.nlm.nih.gov/pubmed/25592962
http://dx.doi.org/10.1186/s12916-014-0250-y
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author Franchini, Massimo
Lippi, Giuseppe
author_facet Franchini, Massimo
Lippi, Giuseppe
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description Other than being present at the surface of red blood cells, the antigens of the ABO blood group system are efficiently expressed by a variety of human cells and tissues. Several studies recently described the involvement of the ABO blood group in the pathogenesis of many human disorders, including cardiovascular disease and cancer, so that its clinical significance extends now beyond the traditional boundaries of transfusion medicine. In a large cohort study recently published in BMC Medicine and including over 50,000 subjects, Etemadi and colleagues reported that nearly 6% of total deaths and as many as 9% of cardiovascular deaths could be attributed to having non-O blood groups, a condition that was also found to be associated with increased risk of gastric cancer. In this commentary, the clinical implications of ABO blood groups are critically discussed and a possible common pathogenic mechanism involving the von Willebrand factor is described. Please see related article http://dx.doi.org/10.1186/s12916-014-0237-8.
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spelling pubmed-42952322015-01-16 The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer Franchini, Massimo Lippi, Giuseppe BMC Med Commentary Other than being present at the surface of red blood cells, the antigens of the ABO blood group system are efficiently expressed by a variety of human cells and tissues. Several studies recently described the involvement of the ABO blood group in the pathogenesis of many human disorders, including cardiovascular disease and cancer, so that its clinical significance extends now beyond the traditional boundaries of transfusion medicine. In a large cohort study recently published in BMC Medicine and including over 50,000 subjects, Etemadi and colleagues reported that nearly 6% of total deaths and as many as 9% of cardiovascular deaths could be attributed to having non-O blood groups, a condition that was also found to be associated with increased risk of gastric cancer. In this commentary, the clinical implications of ABO blood groups are critically discussed and a possible common pathogenic mechanism involving the von Willebrand factor is described. Please see related article http://dx.doi.org/10.1186/s12916-014-0237-8. BioMed Central 2015-01-16 /pmc/articles/PMC4295232/ /pubmed/25592962 http://dx.doi.org/10.1186/s12916-014-0250-y Text en © Franchini and Lippi; licensee BioMed Central. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Commentary
Franchini, Massimo
Lippi, Giuseppe
The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer
title The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer
title_full The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer
title_fullStr The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer
title_full_unstemmed The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer
title_short The intriguing relationship between the ABO blood group, cardiovascular disease, and cancer
title_sort intriguing relationship between the abo blood group, cardiovascular disease, and cancer
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295232/
https://www.ncbi.nlm.nih.gov/pubmed/25592962
http://dx.doi.org/10.1186/s12916-014-0250-y
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