Cargando…

Database screening of herbal monomers regulating autophagy by constructing a "disease-gene-drug" network

BACKGROUND: Studies suggest an important role of autophagy as a target for cancer therapy. We constructed a "disease-gene-drug" network using the modular approach of bioinformatics and screened herbal monomers demonstrating functions related to autophagy regulation. METHODS: Based on the m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hao, Chenjun, Yang, Zhengpeng, Gao, Bo, Lu, Ming, Meng, Xianzhi, Qiao, Xin, Xue, Dongbo, Zhang, Weihui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295301/ https://www.ncbi.nlm.nih.gov/pubmed/25475428 http://dx.doi.org/10.1186/1472-6882-14-466

Ejemplares similares

Screening of differentially expressed protein kinases in bone marrow endothelial cells and the protective effects of the p38a inhibitor SB203580 on bone marrow in liver fibrosis
por: Gao, Bo, et al.
Publicado: (2016)

Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic
por: Miao, Zhuang, et al.
Publicado: (2015)

Application of Competency-Based Education in Laparoscopic Training
por: Xue, Dongbo, et al.
Publicado: (2015)

Is preoperative MRCP necessary for patients with gallstones? An analysis of the factors related to missed diagnosis of choledocholithiasis by preoperative ultrasound
por: Qiu, Yan, et al.
Publicado: (2015)

Regulation of Pancreatic Fibrosis by Acinar Cell-Derived Exosomal miR-130a-3p via Targeting of Stellate Cell PPAR-γ
por: Wang, Qiang, et al.
Publicado: (2021)

Coding and non-coding gene regulatory networks underlie the immune response in liver cirrhosis
por: Gao, Bo, et al.
Publicado: (2017)

Exploring the protective effects of herbal monomers against diabetic retinopathy based on the regulation of autophagy and apoptosis: A review
por: Hu, Zhuoyu, et al.
Publicado: (2023)

Amadis: A Comprehensive Database for Association Between Microbiota and Disease
por: Li, Long, et al.
Publicado: (2021)

Chinese herbal monomers in the treatment of cerebral ischemia/reperfusion injury
Publicado: (2012)

ScRNA-seq and bulk RNA-seq reveal the characteristics of ferroptosis and establish a risk signature in cholangiocarcinoma
por: Yao, Wenchao, et al.
Publicado: (2022)

Intestinal flora imbalance affects bile acid metabolism and is associated with gallstone formation
por: Wang, Qiang, et al.
Publicado: (2020)

ANP32 Family as Diagnostic, Prognostic, and Therapeutic Biomarker Related to Immune Infiltrates in Hepatocellular Carcinoma
por: Liu, Xuxu, et al.
Publicado: (2022)

Effects of Serum Metabolites on the Pancreatic Transcriptome in Acute Acalculous Cholecystitis
por: Sun, Yuanyuan, et al.
Publicado: (2021)

Pancreatic Acinar Cells Employ miRNAs as Mediators of Intercellular Communication to Participate in the Regulation of Pancreatitis-Associated Macrophage Activation
por: Zhao, Yong, et al.
Publicado: (2016)

The Beneficial Effects of Chinese Herbal Monomers on Ameliorating Diabetic Cardiomyopathy via Nrf2 Signaling
por: Gao, Yiwei, et al.
Publicado: (2022)

Effects of Egr1 on pancreatic acinar intracellular trypsinogen activation and the associated ceRNA network
por: Gao, Bo, et al.
Publicado: (2020)

Virtual Screening of Indonesian Herbal Database as HIV-1 Protease Inhibitor
por: Yanuar, Arry, et al.
Publicado: (2014)

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines
por: Ru, Jinlong, et al.
Publicado: (2014)

Changes and Correlations of the Intestinal Flora and Liver Metabolite Profiles in Mice With Gallstones
por: Chen, Yang, et al.
Publicado: (2021)

Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor
por: Syahdi, Rezi Riadhi, et al.
Publicado: (2012)

Synthesis and evaluation of ion-imprinted composite membranes of Cr(vi) based on β-diketone functional monomers
por: Li, Peng, et al.
Publicado: (2021)

Cyclodextrin Monomers and Polymers for Drug Activity Enhancement
por: Matencio, Adrián, et al.
Publicado: (2021)

Thinking on the Construction of Antimicrobial Peptide Databases: Powerful Tools for the Molecular Design and Screening
por: Zhang, Kun, et al.
Publicado: (2023)

Cross-Linking With Diamine Monomers to Prepare Graphene Oxide Composite Membranes With Varying D-Spacing for Enhanced Desalination Properties
por: Ju, Hong, et al.
Publicado: (2021)

CVDHD: a cardiovascular disease herbal database for drug discovery and network pharmacology
por: Gu, Jiangyong, et al.
Publicado: (2013)

Alternative splicing of IRF3 plays an important role in the development of hepatocarcinoma
por: Lv, Zhenyi, et al.
Publicado: (2023)

Perturbation of the Monomer–Monomer Interfaces of the Benzoylformate Decarboxylase Tetramer
por: Andrews, Forest H., et al.
Publicado: (2014)

SWEETLEAD: an In Silico Database of Approved Drugs, Regulated Chemicals, and Herbal Isolates for Computer-Aided Drug Discovery
por: Novick, Paul A., et al.
Publicado: (2013)

Synthesis and characterization of dendritic compounds containing nitrogen: monomer precursors in the construction of biomimetic membranes
por: Guardià, Jordi, et al.
Publicado: (2022)

HIM-herbal ingredients in-vivo metabolism database
por: Kang, Hong, et al.
Publicado: (2013)

HPTLC-Bioluminescent Bioautography Screening of Herbal Teas for Adulteration with Hypolipidemic Drugs
por: Wang, Yuting, et al.
Publicado: (2023)

A novel HCC prognosis predictor PDSS1 affects the cell cycle through the STAT3 signaling pathway in HCC
por: Rao, Zuqin, et al.
Publicado: (2022)

The trigger for pancreatic disease: NLRP3 inflammasome
por: Liu, Tianming, et al.
Publicado: (2023)

Association between high mobility group box-1 protein expression and cell death in acute pancreatitis
por: Gao, Enjun, et al.
Publicado: (2017)

The construction of an efficient magnesium–lithium separation thin film composite membrane with dual aqueous-phase monomers (PIP and MPD)
por: Cheng, Xin, et al.
Publicado: (2023)

Effects of Chinese herbal monomers on oxidative phosphorylation and membrane potential in cerebral mitochondria isolated from hypoxia-exposed rats in vitro★
por: Yan, Weihua, et al.
Publicado: (2012)

Autophagy and Tumor Database: ATdb, a novel database connecting autophagy and tumor
por: Chen, Kelie, et al.
Publicado: (2020)

Construction of TUATinsecta database that integrated plant and insect database for screening phytophagous insect metabolic products with medicinal potential
por: Nakane, Wakana, et al.
Publicado: (2020)

Bioactive Equivalence of Combinatorial Components Identified in Screening of an Herbal Medicine
por: Liu, Peng, et al.
Publicado: (2014)

Biomarker screening in fetal growth restriction based on multiple RNA-seq studies
por: Li, Xiaohui, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_to9sre4ctnosv6gn77sfi8gqv7