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Ontogeny of CpG island methylation and specificity of DNMT3 methyltransferases during embryonic development in the mouse
BACKGROUND: In the mouse, the patterns of DNA methylation are established during early embryonic development in the epiblast. We quantified the targets and kinetics of DNA methylation acquisition in epiblast cells, and determined the contribution of the de novo methyltransferases DNMT3A and DNMT3B t...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295324/ https://www.ncbi.nlm.nih.gov/pubmed/25476147 http://dx.doi.org/10.1186/s13059-014-0545-5 |