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Unraveling the chromosome 17 patterns of FISH in interphase nuclei: an in-depth analysis of the HER2 amplicon and chromosome 17 centromere by karyotyping, FISH and M-FISH in breast cancer cells

BACKGROUND: In diagnostic pathology, HER2 status is determined in interphase nuclei by fluorescence in situ hybridization (FISH) with probes for the HER2 gene and for the chromosome 17 centromere (CEP17). The latter probe is used as a surrogate for chromosome 17 copies, however chromosome 17 (Chr17)...

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Detalles Bibliográficos
Autores principales:	Rondón-Lagos, Milena, Verdun Di Cantogno, Ludovica, Rangel, Nelson, Mele, Teresa, Ramírez-Clavijo, Sandra R, Scagliotti, Giorgio, Marchiò, Caterina, Sapino, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295336/ https://www.ncbi.nlm.nih.gov/pubmed/25481507 http://dx.doi.org/10.1186/1471-2407-14-922

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