Cargando…

Colorectal Cancer and Basement Membranes: Clinicopathological Correlations

Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females. In 2008, an estimated 1.2 million people were diagnosed with and 608,700 people died of CRC. Besides diagnosis and treatment, prognosis is an important matter for cancer patients. Today, clinicopa...

Descripción completa

Detalles Bibliográficos
Autores principales: Mylonas, Charalampos C., Lazaris, Andreas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295340/
https://www.ncbi.nlm.nih.gov/pubmed/25614736
http://dx.doi.org/10.1155/2014/580159
_version_ 1782352830248517632
author Mylonas, Charalampos C.
Lazaris, Andreas C.
author_facet Mylonas, Charalampos C.
Lazaris, Andreas C.
author_sort Mylonas, Charalampos C.
collection PubMed
description Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females. In 2008, an estimated 1.2 million people were diagnosed with and 608,700 people died of CRC. Besides diagnosis and treatment, prognosis is an important matter for cancer patients. Today, clinicopathological correlations have many applications in cancer prognostication. Examples include the prediction of the medium patient survival and the screening for patients suitable for specific therapeutic approaches. Apart from traditional prognostic factors, such as tumor stage and grade, new markers may be useful in clinical practice. Possible markers may result from the study of basement membranes (BMs). BM seems to play a role in the pathogenesis of colorectal cancer, so BM alterations may have prognostic significance as well. The purpose of this review is to briefly describe BMs and their relationship with CRC, in the aspect of clinicopathological correlations.
format Online
Article
Text
id pubmed-4295340
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-42953402015-01-22 Colorectal Cancer and Basement Membranes: Clinicopathological Correlations Mylonas, Charalampos C. Lazaris, Andreas C. Gastroenterol Res Pract Review Article Colorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females. In 2008, an estimated 1.2 million people were diagnosed with and 608,700 people died of CRC. Besides diagnosis and treatment, prognosis is an important matter for cancer patients. Today, clinicopathological correlations have many applications in cancer prognostication. Examples include the prediction of the medium patient survival and the screening for patients suitable for specific therapeutic approaches. Apart from traditional prognostic factors, such as tumor stage and grade, new markers may be useful in clinical practice. Possible markers may result from the study of basement membranes (BMs). BM seems to play a role in the pathogenesis of colorectal cancer, so BM alterations may have prognostic significance as well. The purpose of this review is to briefly describe BMs and their relationship with CRC, in the aspect of clinicopathological correlations. Hindawi Publishing Corporation 2014 2014-12-28 /pmc/articles/PMC4295340/ /pubmed/25614736 http://dx.doi.org/10.1155/2014/580159 Text en Copyright © 2014 C. C. Mylonas and A. C. Lazaris. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mylonas, Charalampos C.
Lazaris, Andreas C.
Colorectal Cancer and Basement Membranes: Clinicopathological Correlations
title Colorectal Cancer and Basement Membranes: Clinicopathological Correlations
title_full Colorectal Cancer and Basement Membranes: Clinicopathological Correlations
title_fullStr Colorectal Cancer and Basement Membranes: Clinicopathological Correlations
title_full_unstemmed Colorectal Cancer and Basement Membranes: Clinicopathological Correlations
title_short Colorectal Cancer and Basement Membranes: Clinicopathological Correlations
title_sort colorectal cancer and basement membranes: clinicopathological correlations
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295340/
https://www.ncbi.nlm.nih.gov/pubmed/25614736
http://dx.doi.org/10.1155/2014/580159
work_keys_str_mv AT mylonascharalamposc colorectalcancerandbasementmembranesclinicopathologicalcorrelations
AT lazarisandreasc colorectalcancerandbasementmembranesclinicopathologicalcorrelations