Host genes and their effect on the intestinal microbiome garden

We are only beginning to understand the relationship between host genetics and the gut microbiome. Two recent studies help to disentangle this interaction and show that genetic loci across the human genome shape the gut microbiome. This opens the possibility that an unexpected number of genetic fact...

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Detalles Bibliográficos
Autores principales: Jacobs, Jonathan, Braun, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Highlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295476/
https://www.ncbi.nlm.nih.gov/pubmed/25593597
http://dx.doi.org/10.1186/s13073-014-0119-x
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author Jacobs, Jonathan
Braun, Jonathan
author_facet Jacobs, Jonathan
Braun, Jonathan
author_sort Jacobs, Jonathan
collection PubMed
description We are only beginning to understand the relationship between host genetics and the gut microbiome. Two recent studies help to disentangle this interaction and show that genetic loci across the human genome shape the gut microbiome. This opens the possibility that an unexpected number of genetic factors act directly on microbial composition and function to modulate immune pathways and metabolic phenotypes in host physiology and disease.
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spelling pubmed-42954762015-01-16 Host genes and their effect on the intestinal microbiome garden Jacobs, Jonathan Braun, Jonathan Genome Med Research Highlight We are only beginning to understand the relationship between host genetics and the gut microbiome. Two recent studies help to disentangle this interaction and show that genetic loci across the human genome shape the gut microbiome. This opens the possibility that an unexpected number of genetic factors act directly on microbial composition and function to modulate immune pathways and metabolic phenotypes in host physiology and disease. BioMed Central 2014-12-17 /pmc/articles/PMC4295476/ /pubmed/25593597 http://dx.doi.org/10.1186/s13073-014-0119-x Text en © Jacobs and Braun; licensee BioMed Central Ltd. 2014 The licensee has exclusive rights to distribute this article, in any medium, for 12 months following its publication. After this time, the article is available under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Highlight
Jacobs, Jonathan
Braun, Jonathan
Host genes and their effect on the intestinal microbiome garden
title Host genes and their effect on the intestinal microbiome garden
title_full Host genes and their effect on the intestinal microbiome garden
title_fullStr Host genes and their effect on the intestinal microbiome garden
title_full_unstemmed Host genes and their effect on the intestinal microbiome garden
title_short Host genes and their effect on the intestinal microbiome garden
title_sort host genes and their effect on the intestinal microbiome garden
topic Research Highlight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295476/
https://www.ncbi.nlm.nih.gov/pubmed/25593597
http://dx.doi.org/10.1186/s13073-014-0119-x
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