Vitamin D status, receptor gene polymorphisms, and supplementation on tuberculosis: A systematic review of case-control studies and randomized controlled trials()

OBJECTIVE: To investigate the impacts of vitamin D status, supplementation and vitamin D receptor (VDR) gene polymorphisms on tuberculosis (TB). METHODS: We conducted a systematic review of published studies pertaining to case–control and randomized-control trials from 2002 to 2014 using the PubMed...

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Detalles Bibliográficos
Autores principales: Sutaria, Nilay, Liu, Ching-Ti, Chen, Tai C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295520/
https://www.ncbi.nlm.nih.gov/pubmed/25599020
http://dx.doi.org/10.1016/j.jcte.2014.08.001
Descripción
Sumario:OBJECTIVE: To investigate the impacts of vitamin D status, supplementation and vitamin D receptor (VDR) gene polymorphisms on tuberculosis (TB). METHODS: We conducted a systematic review of published studies pertaining to case–control and randomized-control trials from 2002 to 2014 using the PubMed database. RESULTS AND CONCLUSION: Individuals with TB have lower vitamin D status than healthy individuals. Some VDR gene polymorphisms are associated with increased susceptibility to TB while others may not. Supplementation with vitamin D leads to improved clinical outcomes. However, further studies with a larger patient population and different ethnicities are needed to confirm these effects.

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