Interplay Between HGF/SF–Met-Ras Signaling, Tumor Metabolism and Blood Flow as a Potential Target for Breast Cancer Therapy

High glucose uptake and increase blood flow is a characteristic of most metastatic tumors. Activation of Ras signaling increases glycolytic flux into lactate, de novo nucleic acid synthesis and uncoupling of ATP synthase from the proton gradient. Met tyrosine kinase receptor signaling upon activatio...

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Detalles Bibliográficos
Autores principales: Natan, Sari, Tsarfaty, Galia, Horev, Judith, Haklai, Roni, Kloog, Yoel, Tsarfaty, Ilan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2013
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295761/
https://www.ncbi.nlm.nih.gov/pubmed/25593982

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