Elucidation of the Interaction Loci of the Human Pyruvate Dehydrogenase Complex E2·E3BP Core with Pyruvate Dehydrogenase Kinase 1 and Kinase 2 by H/D Exchange Mass Spectrometry and Nuclear Magnetic Resonance

[Image: see text] The human pyruvate dehydrogenase complex (PDC) comprises three principal catalytic components for its mission: E1, E2, and E3. The core of the complex is a strong subcomplex between E2 and an E3-binding protein (E3BP). The PDC is subject to regulation at E1 by serine phosphorylatio...

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Autores principales: Wang, Junjie, Kumaran, Sowmini, Zhou, Jieyu, Nemeria, Natalia S., Tao, Hu, Kakalis, Lazaros, Park, Yun-Hee, Birkaya, Barbara, Patel, Mulchand S., Jordan, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295793/
https://www.ncbi.nlm.nih.gov/pubmed/25436986
http://dx.doi.org/10.1021/bi5013113

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