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Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation
A key element to delineate the biology of individual tumors is the regulation of apoptosis. In this work, we functionally characterize two breast cancer associated genes, the proteasome 26S subunit ATPase 3 interacting protein (PSMC3IP) and the epithelial-stromal interaction 1 (EPSTI1), to explore t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295872/ https://www.ncbi.nlm.nih.gov/pubmed/25590583 http://dx.doi.org/10.1371/journal.pone.0115352 |
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author | Capdevila-Busquets, Eva Badiola, Nahuai Arroyo, Rodrigo Alcalde, Víctor Soler-López, Montserrat Aloy, Patrick |
author_facet | Capdevila-Busquets, Eva Badiola, Nahuai Arroyo, Rodrigo Alcalde, Víctor Soler-López, Montserrat Aloy, Patrick |
author_sort | Capdevila-Busquets, Eva |
collection | PubMed |
description | A key element to delineate the biology of individual tumors is the regulation of apoptosis. In this work, we functionally characterize two breast cancer associated genes, the proteasome 26S subunit ATPase 3 interacting protein (PSMC3IP) and the epithelial-stromal interaction 1 (EPSTI1), to explore their potential apoptotic role in breast cancer. We first explore the existence of direct physical interactions with annotated BC-apoptotic genes. Based on the generated interaction network, we examine several apoptotic markers to determine the effect of PSMC3IP and EPSTI1 gene expression modulation in two different human breast cancer cell lines to suggest potential molecular mechanisms to unveil their role in the disease. Our results show that PSMC3IP and EPSTI1 are able to modulate the extrinsic apoptotic pathway in estrogen receptor positive and triple negative breast cancer cell lines, highlighting them as potential therapeutic targets. |
format | Online Article Text |
id | pubmed-4295872 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-42958722015-01-22 Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation Capdevila-Busquets, Eva Badiola, Nahuai Arroyo, Rodrigo Alcalde, Víctor Soler-López, Montserrat Aloy, Patrick PLoS One Research Article A key element to delineate the biology of individual tumors is the regulation of apoptosis. In this work, we functionally characterize two breast cancer associated genes, the proteasome 26S subunit ATPase 3 interacting protein (PSMC3IP) and the epithelial-stromal interaction 1 (EPSTI1), to explore their potential apoptotic role in breast cancer. We first explore the existence of direct physical interactions with annotated BC-apoptotic genes. Based on the generated interaction network, we examine several apoptotic markers to determine the effect of PSMC3IP and EPSTI1 gene expression modulation in two different human breast cancer cell lines to suggest potential molecular mechanisms to unveil their role in the disease. Our results show that PSMC3IP and EPSTI1 are able to modulate the extrinsic apoptotic pathway in estrogen receptor positive and triple negative breast cancer cell lines, highlighting them as potential therapeutic targets. Public Library of Science 2015-01-15 /pmc/articles/PMC4295872/ /pubmed/25590583 http://dx.doi.org/10.1371/journal.pone.0115352 Text en © 2015 Capdevila-Busquets et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Capdevila-Busquets, Eva Badiola, Nahuai Arroyo, Rodrigo Alcalde, Víctor Soler-López, Montserrat Aloy, Patrick Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation |
title | Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation |
title_full | Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation |
title_fullStr | Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation |
title_full_unstemmed | Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation |
title_short | Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation |
title_sort | breast cancer genes psmc3ip and epsti1 play a role in apoptosis regulation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4295872/ https://www.ncbi.nlm.nih.gov/pubmed/25590583 http://dx.doi.org/10.1371/journal.pone.0115352 |
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