Hepatocellular Carcinoma in a Noncirrhotic Liver after Long-Term Use of Danazol for Hereditary Angioedema

We report a 57-year-old male who was treated with high-dose danazol for hereditary angioedema for more than 30 years; he developed hepatocellular carcinoma in the absence of cirrhosis. Despite surgical resection, he had a recurrence and received sorafenib, but had a poor skin tolerance. Such tumors...

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Detalles Bibliográficos
Autores principales: Rahal, Soraya, Gilabert, Marine, Ries, Pauline, Oziel-Taieb, Sandrine, Dermeche, Slimane, Raoul, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Published online: December, 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296231/
https://www.ncbi.nlm.nih.gov/pubmed/25606032
http://dx.doi.org/10.1159/000370106
Descripción
Sumario:We report a 57-year-old male who was treated with high-dose danazol for hereditary angioedema for more than 30 years; he developed hepatocellular carcinoma in the absence of cirrhosis. Despite surgical resection, he had a recurrence and received sorafenib, but had a poor skin tolerance. Such tumors arising after danazol are infrequent, and this case is highly unique due to the minor lesions found on the liver.

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