Hepatocellular Carcinoma in a Noncirrhotic Liver after Long-Term Use of Danazol for Hereditary Angioedema

We report a 57-year-old male who was treated with high-dose danazol for hereditary angioedema for more than 30 years; he developed hepatocellular carcinoma in the absence of cirrhosis. Despite surgical resection, he had a recurrence and received sorafenib, but had a poor skin tolerance. Such tumors...

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Autores principales: Rahal, Soraya, Gilabert, Marine, Ries, Pauline, Oziel-Taieb, Sandrine, Dermeche, Slimane, Raoul, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2014
Materias:
Published online: December, 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296231/
https://www.ncbi.nlm.nih.gov/pubmed/25606032
http://dx.doi.org/10.1159/000370106
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author Rahal, Soraya
Gilabert, Marine
Ries, Pauline
Oziel-Taieb, Sandrine
Dermeche, Slimane
Raoul, Jean-Luc
author_facet Rahal, Soraya
Gilabert, Marine
Ries, Pauline
Oziel-Taieb, Sandrine
Dermeche, Slimane
Raoul, Jean-Luc
author_sort Rahal, Soraya
collection PubMed
description We report a 57-year-old male who was treated with high-dose danazol for hereditary angioedema for more than 30 years; he developed hepatocellular carcinoma in the absence of cirrhosis. Despite surgical resection, he had a recurrence and received sorafenib, but had a poor skin tolerance. Such tumors arising after danazol are infrequent, and this case is highly unique due to the minor lesions found on the liver.
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spelling pubmed-42962312015-01-20 Hepatocellular Carcinoma in a Noncirrhotic Liver after Long-Term Use of Danazol for Hereditary Angioedema Rahal, Soraya Gilabert, Marine Ries, Pauline Oziel-Taieb, Sandrine Dermeche, Slimane Raoul, Jean-Luc Case Rep Oncol Published online: December, 2014 We report a 57-year-old male who was treated with high-dose danazol for hereditary angioedema for more than 30 years; he developed hepatocellular carcinoma in the absence of cirrhosis. Despite surgical resection, he had a recurrence and received sorafenib, but had a poor skin tolerance. Such tumors arising after danazol are infrequent, and this case is highly unique due to the minor lesions found on the liver. S. Karger AG 2014-12-09 /pmc/articles/PMC4296231/ /pubmed/25606032 http://dx.doi.org/10.1159/000370106 Text en Copyright © 2014 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license (CC BY-NC) (www.karger.com/OA-license), applicable to the online version of the article only. Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions.
spellingShingle Published online: December, 2014
Rahal, Soraya
Gilabert, Marine
Ries, Pauline
Oziel-Taieb, Sandrine
Dermeche, Slimane
Raoul, Jean-Luc
Hepatocellular Carcinoma in a Noncirrhotic Liver after Long-Term Use of Danazol for Hereditary Angioedema
title Hepatocellular Carcinoma in a Noncirrhotic Liver after Long-Term Use of Danazol for Hereditary Angioedema
title_full Hepatocellular Carcinoma in a Noncirrhotic Liver after Long-Term Use of Danazol for Hereditary Angioedema
title_fullStr Hepatocellular Carcinoma in a Noncirrhotic Liver after Long-Term Use of Danazol for Hereditary Angioedema
title_full_unstemmed Hepatocellular Carcinoma in a Noncirrhotic Liver after Long-Term Use of Danazol for Hereditary Angioedema
title_short Hepatocellular Carcinoma in a Noncirrhotic Liver after Long-Term Use of Danazol for Hereditary Angioedema
title_sort hepatocellular carcinoma in a noncirrhotic liver after long-term use of danazol for hereditary angioedema
topic Published online: December, 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296231/
https://www.ncbi.nlm.nih.gov/pubmed/25606032
http://dx.doi.org/10.1159/000370106
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