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Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4
Experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), results from an autoimmune attack of the central nervous system (CNS) by effector T helper (Th) 1 and Th17 cells. Regulatory T cells (Treg) can control effector T cells and limit the progression of CNS auto...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296287/ https://www.ncbi.nlm.nih.gov/pubmed/25592296 http://dx.doi.org/10.1038/srep07834 |
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author | Glatigny, Simon Duhen, Rebekka Arbelaez, Carlos Kumari, Swarnima Bettelli, Estelle |
author_facet | Glatigny, Simon Duhen, Rebekka Arbelaez, Carlos Kumari, Swarnima Bettelli, Estelle |
author_sort | Glatigny, Simon |
collection | PubMed |
description | Experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), results from an autoimmune attack of the central nervous system (CNS) by effector T helper (Th) 1 and Th17 cells. Regulatory T cells (Treg) can control effector T cells and limit the progression of CNS autoimmunity. Integrin alpha 4 (Itga4) is critical for the entry of Th1 but not Th17 cells into the CNS during EAE. Whether Itga4 controls the homing of Tregs in the CNS and whether Tregs can limit Th17-mediated EAE has, however, not been addressed. Through selective elimination of Itga4 in Foxp3-expressing cells, we show here that Tregs can suppress Th17-mediated EAE and enter into the CNS independently of Itga4. Furthermore, similarly to Th17 cells and in contrast to Th1 cells, Tregs depend on LFA-1 for their entry into the CNS in the absence of Itga4. Therefore, these data suggest that the efficacy of Itga4 neutralization on MS progression may be associated with the prevention of Th1 cells and the maintenance of Tregs migration into the CNS. |
format | Online Article Text |
id | pubmed-4296287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-42962872015-01-16 Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4 Glatigny, Simon Duhen, Rebekka Arbelaez, Carlos Kumari, Swarnima Bettelli, Estelle Sci Rep Article Experimental autoimmune encephalomyelitis (EAE), the animal model of multiple sclerosis (MS), results from an autoimmune attack of the central nervous system (CNS) by effector T helper (Th) 1 and Th17 cells. Regulatory T cells (Treg) can control effector T cells and limit the progression of CNS autoimmunity. Integrin alpha 4 (Itga4) is critical for the entry of Th1 but not Th17 cells into the CNS during EAE. Whether Itga4 controls the homing of Tregs in the CNS and whether Tregs can limit Th17-mediated EAE has, however, not been addressed. Through selective elimination of Itga4 in Foxp3-expressing cells, we show here that Tregs can suppress Th17-mediated EAE and enter into the CNS independently of Itga4. Furthermore, similarly to Th17 cells and in contrast to Th1 cells, Tregs depend on LFA-1 for their entry into the CNS in the absence of Itga4. Therefore, these data suggest that the efficacy of Itga4 neutralization on MS progression may be associated with the prevention of Th1 cells and the maintenance of Tregs migration into the CNS. Nature Publishing Group 2015-01-16 /pmc/articles/PMC4296287/ /pubmed/25592296 http://dx.doi.org/10.1038/srep07834 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ |
spellingShingle | Article Glatigny, Simon Duhen, Rebekka Arbelaez, Carlos Kumari, Swarnima Bettelli, Estelle Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4 |
title | Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4 |
title_full | Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4 |
title_fullStr | Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4 |
title_full_unstemmed | Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4 |
title_short | Integrin alpha L controls the homing of regulatory T cells during CNS autoimmunity in the absence of integrin alpha 4 |
title_sort | integrin alpha l controls the homing of regulatory t cells during cns autoimmunity in the absence of integrin alpha 4 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296287/ https://www.ncbi.nlm.nih.gov/pubmed/25592296 http://dx.doi.org/10.1038/srep07834 |
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