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Human umbilical cord blood-derived mesenchymal stem cells promote regeneration of crush-injured rat sciatic nerves★

Several studies have demonstrated that human umbilical cord blood-derived mesenchymal stem cells can promote neural regeneration following brain injury. However, the therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells in guiding peripheral nerve regeneration remain poorl...

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Detalles Bibliográficos
Autores principales: Sung, Mi-Ae, Jung, Hun Jong, Lee, Jung-Woo, Lee, Jin-Yong, Pang, Kang-Mi, Yoo, Sang Bae, Alrashdan, Mohammad S., Kim, Soung-Min, Jahng, Jeong Won, Lee, Jong-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296421/
https://www.ncbi.nlm.nih.gov/pubmed/25624833
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.26.003
Descripción
Sumario:Several studies have demonstrated that human umbilical cord blood-derived mesenchymal stem cells can promote neural regeneration following brain injury. However, the therapeutic effects of human umbilical cord blood-derived mesenchymal stem cells in guiding peripheral nerve regeneration remain poorly understood. This study was designed to investigate the effects of human umbilical cord blood-derived mesenchymal stem cells on neural regeneration using a rat sciatic nerve crush injury model. Human umbilical cord blood-derived mesenchymal stem cells (1 × 10(6)) or a PBS control were injected into the crush-injured segment of the sciatic nerve. Four weeks after cell injection, brain-derived neurotrophic factor and tyrosine kinase receptor B mRNA expression at the lesion site was increased in comparison to control. Furthermore, sciatic function index, Fluoro Gold-labeled neuron counts and axon density were also significantly increased when compared with control. Our results indicate that human umbilical cord blood-derived mesenchymal stem cells promote the functional recovery of crush-injured sciatic nerves.