Clinical and radiographic evaluation of recombinant human platelet derived growth factor with beta tricalcium phosphate in the treatment of a periodontal intrabony defect

The need to increase the predictability of successful periodontal regeneration has led to the use of cell-stimulating proteins in combination with osteoconductive scaffolds and cells based on the principles of tissue engineering. The present case report describes the treatment of an intrabony defect with recombinant human platelet derived growth factor (rhPDGF) + β-tricalcium phosphate (β-TCP). A 25-year-old patient presented with a probing pocket depth of 9 mm mesial to the left maxillary molar. The radiograph revealed an intrabony defect with a depth of 4.23 mm. The defect was treated by open flap debridement and grafting with rhPDGF + β-TCP. On 9 months follow-up, the pocket depth reduced to 3 mm and the defect was completely filled as observed in radiographs and surgical re-entry. A gain in alveolar crest height was also observed.