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The use of bisphosphonates does not contraindicate orthodontic and other types of treatment!

Bisphosphonates have been increasingly used not only to treat bone diseases as well as conditions such as osteopenia and osteoporosis, but also in oncotherapy. The use of bisphosphonates induces clinicians to fear and care. These reactions are associated with controversy resulting from lack of in-de...

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Detalles Bibliográficos
Autor principal: Consolaro, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dental Press International 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296645/
https://www.ncbi.nlm.nih.gov/pubmed/25279517
http://dx.doi.org/10.1590/2176-9451.19.4.018-026.oin
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author Consolaro, Alberto
author_facet Consolaro, Alberto
author_sort Consolaro, Alberto
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description Bisphosphonates have been increasingly used not only to treat bone diseases as well as conditions such as osteopenia and osteoporosis, but also in oncotherapy. The use of bisphosphonates induces clinicians to fear and care. These reactions are associated with controversy resulting from lack of in-depth knowledge on the mechanisms of action as well as lack of a more accurate assessment of side effects. Scientific and clinical knowledge disclosure greatly contributes to professionals' discernment and inner balance, especially orthodontists. Fear does not lead to awareness. For these reasons, we present an article that focuses on that matter. This article was adapted from different journals of different dental specialties, as mentioned on footnote. There is no scientific evidence demonstrating that bisphosphonates are directly involved with etiopathogenic mechanisms of osteonecrosis and jaw osteomyelitis. Their use is contraindicated and limited in cases of dental treatment involving bone tissue. Nevertheless, such fact is based on professional opinion, case reports, and personal experience or experiment trials with failing methods. Additional studies will always be necessary; however, in-depth knowledge on bone biology is of paramount importance to offer an opinion about the clinical use of bisphosphonates and their further implications. Based on bone biopathology, this article aims at contributing to lay the groundwork for this matter.
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spelling pubmed-42966452015-01-26 The use of bisphosphonates does not contraindicate orthodontic and other types of treatment! Consolaro, Alberto Dental Press J Orthod Orthodontic Insight Bisphosphonates have been increasingly used not only to treat bone diseases as well as conditions such as osteopenia and osteoporosis, but also in oncotherapy. The use of bisphosphonates induces clinicians to fear and care. These reactions are associated with controversy resulting from lack of in-depth knowledge on the mechanisms of action as well as lack of a more accurate assessment of side effects. Scientific and clinical knowledge disclosure greatly contributes to professionals' discernment and inner balance, especially orthodontists. Fear does not lead to awareness. For these reasons, we present an article that focuses on that matter. This article was adapted from different journals of different dental specialties, as mentioned on footnote. There is no scientific evidence demonstrating that bisphosphonates are directly involved with etiopathogenic mechanisms of osteonecrosis and jaw osteomyelitis. Their use is contraindicated and limited in cases of dental treatment involving bone tissue. Nevertheless, such fact is based on professional opinion, case reports, and personal experience or experiment trials with failing methods. Additional studies will always be necessary; however, in-depth knowledge on bone biology is of paramount importance to offer an opinion about the clinical use of bisphosphonates and their further implications. Based on bone biopathology, this article aims at contributing to lay the groundwork for this matter. Dental Press International 2014 /pmc/articles/PMC4296645/ /pubmed/25279517 http://dx.doi.org/10.1590/2176-9451.19.4.018-026.oin Text en © 2014 Dental Press Journal of Orthodontics http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Orthodontic Insight
Consolaro, Alberto
The use of bisphosphonates does not contraindicate orthodontic and other types of treatment!
title The use of bisphosphonates does not contraindicate orthodontic and other types of treatment!
title_full The use of bisphosphonates does not contraindicate orthodontic and other types of treatment!
title_fullStr The use of bisphosphonates does not contraindicate orthodontic and other types of treatment!
title_full_unstemmed The use of bisphosphonates does not contraindicate orthodontic and other types of treatment!
title_short The use of bisphosphonates does not contraindicate orthodontic and other types of treatment!
title_sort use of bisphosphonates does not contraindicate orthodontic and other types of treatment!
topic Orthodontic Insight
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296645/
https://www.ncbi.nlm.nih.gov/pubmed/25279517
http://dx.doi.org/10.1590/2176-9451.19.4.018-026.oin
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