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The use of bisphosphonates does not contraindicate orthodontic and other types of treatment!
Bisphosphonates have been increasingly used not only to treat bone diseases as well as conditions such as osteopenia and osteoporosis, but also in oncotherapy. The use of bisphosphonates induces clinicians to fear and care. These reactions are associated with controversy resulting from lack of in-de...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dental Press International
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296645/ https://www.ncbi.nlm.nih.gov/pubmed/25279517 http://dx.doi.org/10.1590/2176-9451.19.4.018-026.oin |
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author | Consolaro, Alberto |
author_facet | Consolaro, Alberto |
author_sort | Consolaro, Alberto |
collection | PubMed |
description | Bisphosphonates have been increasingly used not only to treat bone diseases as well as conditions such as osteopenia and osteoporosis, but also in oncotherapy. The use of bisphosphonates induces clinicians to fear and care. These reactions are associated with controversy resulting from lack of in-depth knowledge on the mechanisms of action as well as lack of a more accurate assessment of side effects. Scientific and clinical knowledge disclosure greatly contributes to professionals' discernment and inner balance, especially orthodontists. Fear does not lead to awareness. For these reasons, we present an article that focuses on that matter. This article was adapted from different journals of different dental specialties, as mentioned on footnote. There is no scientific evidence demonstrating that bisphosphonates are directly involved with etiopathogenic mechanisms of osteonecrosis and jaw osteomyelitis. Their use is contraindicated and limited in cases of dental treatment involving bone tissue. Nevertheless, such fact is based on professional opinion, case reports, and personal experience or experiment trials with failing methods. Additional studies will always be necessary; however, in-depth knowledge on bone biology is of paramount importance to offer an opinion about the clinical use of bisphosphonates and their further implications. Based on bone biopathology, this article aims at contributing to lay the groundwork for this matter. |
format | Online Article Text |
id | pubmed-4296645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Dental Press International |
record_format | MEDLINE/PubMed |
spelling | pubmed-42966452015-01-26 The use of bisphosphonates does not contraindicate orthodontic and other types of treatment! Consolaro, Alberto Dental Press J Orthod Orthodontic Insight Bisphosphonates have been increasingly used not only to treat bone diseases as well as conditions such as osteopenia and osteoporosis, but also in oncotherapy. The use of bisphosphonates induces clinicians to fear and care. These reactions are associated with controversy resulting from lack of in-depth knowledge on the mechanisms of action as well as lack of a more accurate assessment of side effects. Scientific and clinical knowledge disclosure greatly contributes to professionals' discernment and inner balance, especially orthodontists. Fear does not lead to awareness. For these reasons, we present an article that focuses on that matter. This article was adapted from different journals of different dental specialties, as mentioned on footnote. There is no scientific evidence demonstrating that bisphosphonates are directly involved with etiopathogenic mechanisms of osteonecrosis and jaw osteomyelitis. Their use is contraindicated and limited in cases of dental treatment involving bone tissue. Nevertheless, such fact is based on professional opinion, case reports, and personal experience or experiment trials with failing methods. Additional studies will always be necessary; however, in-depth knowledge on bone biology is of paramount importance to offer an opinion about the clinical use of bisphosphonates and their further implications. Based on bone biopathology, this article aims at contributing to lay the groundwork for this matter. Dental Press International 2014 /pmc/articles/PMC4296645/ /pubmed/25279517 http://dx.doi.org/10.1590/2176-9451.19.4.018-026.oin Text en © 2014 Dental Press Journal of Orthodontics http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Orthodontic Insight Consolaro, Alberto The use of bisphosphonates does not contraindicate orthodontic and other types of treatment! |
title | The use of bisphosphonates does not contraindicate orthodontic and other
types of treatment! |
title_full | The use of bisphosphonates does not contraindicate orthodontic and other
types of treatment! |
title_fullStr | The use of bisphosphonates does not contraindicate orthodontic and other
types of treatment! |
title_full_unstemmed | The use of bisphosphonates does not contraindicate orthodontic and other
types of treatment! |
title_short | The use of bisphosphonates does not contraindicate orthodontic and other
types of treatment! |
title_sort | use of bisphosphonates does not contraindicate orthodontic and other
types of treatment! |
topic | Orthodontic Insight |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296645/ https://www.ncbi.nlm.nih.gov/pubmed/25279517 http://dx.doi.org/10.1590/2176-9451.19.4.018-026.oin |
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