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Senescence marker protein-30/gluconolactonase deficiency exacerbates diabetic nephropathy through tubular injury in a mouse model of type 1 diabetes
AIMS/INTRODUCTION: Senescence marker protein-30 (SMP30) is abundantly expressed in renal proximal tubule cells, but its expression decreases with age. Previous studies have shown that reduced SMP30 expression could contribute to aging-associated deterioration of cellular function and tissue injury....
Autores principales: | Okada, Hiroshi, Senmaru, Takafumi, Fukui, Michiaki, Kondo, Yoshitaka, Ishigami, Akihito, Maruyama, Naoki, Obayashi, Hiroshi, Yamazaki, Masahiro, Nakamura, Naoto, Hasegawa, Goji |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296701/ https://www.ncbi.nlm.nih.gov/pubmed/25621131 http://dx.doi.org/10.1111/jdi.12252 |
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