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MET-Amplified Intramucosal Gastric Cancer Widely Metastatic after Complete Endoscopic Submucosal Dissection

Intramucosal gastric cancer (IGC) is associated with a very low risk of lymph node metastasis; thus it is the main candidate for minimally invasive surgical procedures, such as endoscopic submucosal dissection (ESD). Herein, we document an extraordinary case of IGC, which showed a very aggressive cl...

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Autores principales: Lee, Dakeun, Kim, Young Chul, Lee, Kee Myung, Yoon, Joon-Kee, Kim, Young-Bae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296859/
https://www.ncbi.nlm.nih.gov/pubmed/25152190
http://dx.doi.org/10.4143/crt.2013.137
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author Lee, Dakeun
Kim, Young Chul
Lee, Kee Myung
Yoon, Joon-Kee
Kim, Young-Bae
author_facet Lee, Dakeun
Kim, Young Chul
Lee, Kee Myung
Yoon, Joon-Kee
Kim, Young-Bae
author_sort Lee, Dakeun
collection PubMed
description Intramucosal gastric cancer (IGC) is associated with a very low risk of lymph node metastasis; thus it is the main candidate for minimally invasive surgical procedures, such as endoscopic submucosal dissection (ESD). Herein, we document an extraordinary case of IGC, which showed a very aggressive clinical course. A 66-year-old female underwent ESD for early gastric cancer. Histologically, the tumor consisted mainly of moderately differentiated adenocarcinoma measuring 1.6 cm in diameter, and the tumor was confined to the mucosa. Despite annual esophagogastroduodenoscopic follow-up, the tumor recurred, with wide metastasis to multiple lymph nodes and bones throughout the body after three years. Fluorescence in situ hybridization study demonstrated MET gene amplification as well as low grade polysomy 7 in both original and recurrent tumors. The clinical characteristics of metastatic IGCs and the implication of MET amplification are discussed.
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spelling pubmed-42968592015-01-20 MET-Amplified Intramucosal Gastric Cancer Widely Metastatic after Complete Endoscopic Submucosal Dissection Lee, Dakeun Kim, Young Chul Lee, Kee Myung Yoon, Joon-Kee Kim, Young-Bae Cancer Res Treat Case Report Intramucosal gastric cancer (IGC) is associated with a very low risk of lymph node metastasis; thus it is the main candidate for minimally invasive surgical procedures, such as endoscopic submucosal dissection (ESD). Herein, we document an extraordinary case of IGC, which showed a very aggressive clinical course. A 66-year-old female underwent ESD for early gastric cancer. Histologically, the tumor consisted mainly of moderately differentiated adenocarcinoma measuring 1.6 cm in diameter, and the tumor was confined to the mucosa. Despite annual esophagogastroduodenoscopic follow-up, the tumor recurred, with wide metastasis to multiple lymph nodes and bones throughout the body after three years. Fluorescence in situ hybridization study demonstrated MET gene amplification as well as low grade polysomy 7 in both original and recurrent tumors. The clinical characteristics of metastatic IGCs and the implication of MET amplification are discussed. Korean Cancer Association 2015-01 2014-08-25 /pmc/articles/PMC4296859/ /pubmed/25152190 http://dx.doi.org/10.4143/crt.2013.137 Text en Copyright © 2015 by the Korean Cancer Association This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/)which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lee, Dakeun
Kim, Young Chul
Lee, Kee Myung
Yoon, Joon-Kee
Kim, Young-Bae
MET-Amplified Intramucosal Gastric Cancer Widely Metastatic after Complete Endoscopic Submucosal Dissection
title MET-Amplified Intramucosal Gastric Cancer Widely Metastatic after Complete Endoscopic Submucosal Dissection
title_full MET-Amplified Intramucosal Gastric Cancer Widely Metastatic after Complete Endoscopic Submucosal Dissection
title_fullStr MET-Amplified Intramucosal Gastric Cancer Widely Metastatic after Complete Endoscopic Submucosal Dissection
title_full_unstemmed MET-Amplified Intramucosal Gastric Cancer Widely Metastatic after Complete Endoscopic Submucosal Dissection
title_short MET-Amplified Intramucosal Gastric Cancer Widely Metastatic after Complete Endoscopic Submucosal Dissection
title_sort met-amplified intramucosal gastric cancer widely metastatic after complete endoscopic submucosal dissection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296859/
https://www.ncbi.nlm.nih.gov/pubmed/25152190
http://dx.doi.org/10.4143/crt.2013.137
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