Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons

[Image: see text] We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson–Crick base pairing program that builds the nanostructures allowed us to probe independen...

Descripción completa

Detalles Bibliográficos
Autores principales: Stephanopoulos, Nicholas, Freeman, Ronit, North, Hilary A., Sur, Shantanu, Jeong, Su Ji, Tantakitti, Faifan, Kessler, John A., Stupp, Samuel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296924/
https://www.ncbi.nlm.nih.gov/pubmed/25546084
http://dx.doi.org/10.1021/nl504079q
Descripción
Sumario:[Image: see text] We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson–Crick base pairing program that builds the nanostructures allowed us to probe independently the effect of nanotube architecture and peptide bioactivity on stem cell differentiation. We found that both factors instruct synergistically the preferential differentiation of the cells into neurons rather than astrocytes.

Ejemplares similares