Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons

[Image: see text] We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson–Crick base pairing program that builds the nanostructures allowed us to probe independen...

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Autores principales: Stephanopoulos, Nicholas, Freeman, Ronit, North, Hilary A., Sur, Shantanu, Jeong, Su Ji, Tantakitti, Faifan, Kessler, John A., Stupp, Samuel I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296924/
https://www.ncbi.nlm.nih.gov/pubmed/25546084
http://dx.doi.org/10.1021/nl504079q
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author Stephanopoulos, Nicholas
Freeman, Ronit
North, Hilary A.
Sur, Shantanu
Jeong, Su Ji
Tantakitti, Faifan
Kessler, John A.
Stupp, Samuel I.
author_facet Stephanopoulos, Nicholas
Freeman, Ronit
North, Hilary A.
Sur, Shantanu
Jeong, Su Ji
Tantakitti, Faifan
Kessler, John A.
Stupp, Samuel I.
author_sort Stephanopoulos, Nicholas
collection PubMed
description [Image: see text] We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson–Crick base pairing program that builds the nanostructures allowed us to probe independently the effect of nanotube architecture and peptide bioactivity on stem cell differentiation. We found that both factors instruct synergistically the preferential differentiation of the cells into neurons rather than astrocytes.
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spelling pubmed-42969242015-12-29 Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons Stephanopoulos, Nicholas Freeman, Ronit North, Hilary A. Sur, Shantanu Jeong, Su Ji Tantakitti, Faifan Kessler, John A. Stupp, Samuel I. Nano Lett [Image: see text] We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson–Crick base pairing program that builds the nanostructures allowed us to probe independently the effect of nanotube architecture and peptide bioactivity on stem cell differentiation. We found that both factors instruct synergistically the preferential differentiation of the cells into neurons rather than astrocytes. American Chemical Society 2014-12-29 2015-01-14 /pmc/articles/PMC4296924/ /pubmed/25546084 http://dx.doi.org/10.1021/nl504079q Text en Copyright © 2014 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Stephanopoulos, Nicholas
Freeman, Ronit
North, Hilary A.
Sur, Shantanu
Jeong, Su Ji
Tantakitti, Faifan
Kessler, John A.
Stupp, Samuel I.
Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons
title Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons
title_full Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons
title_fullStr Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons
title_full_unstemmed Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons
title_short Bioactive DNA-Peptide Nanotubes Enhance the Differentiation of Neural Stem Cells Into Neurons
title_sort bioactive dna-peptide nanotubes enhance the differentiation of neural stem cells into neurons
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296924/
https://www.ncbi.nlm.nih.gov/pubmed/25546084
http://dx.doi.org/10.1021/nl504079q
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