Cargando…
Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle
OBJECTIVE: Metabolic derangements, including insulin resistance and hyperlactatemia, are a major complication of major trauma (e.g., burn injury) and affect the prognosis of burn patients. Protein farnesylation, a posttranslational lipid modification of cysteine residues, has been emerging as a pote...
Autores principales: | Nakazawa, Harumasa, Yamada, Marina, Tanaka, Tomokazu, Kramer, Joshua, Yu, Yong-Ming, Fischman, Alan J., Martyn, J. A. Jeevendra, Tompkins, Ronald G., Kaneki, Masao |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296934/ https://www.ncbi.nlm.nih.gov/pubmed/25594415 http://dx.doi.org/10.1371/journal.pone.0116633 |
Ejemplares similares
-
Burn-induced muscle metabolic derangements and mitochondrial dysfunction are associated with activation of HIF-1α and mTORC1: Role of protein farnesylation
por: Nakazawa, Harumasa, et al.
Publicado: (2017) -
Coenzyme Q10 protects against burn‐induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle
por: Nakazawa, Harumasa, et al.
Publicado: (2019) -
iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53
por: Nakazawa, Harumasa, et al.
Publicado: (2017) -
Farnesyltransferase inhibitors prevent HIV protease inhibitor (lopinavir/ritonavir)-induced lipodystrophy and metabolic syndrome in mice
por: Tanaka, Tomokazu, et al.
Publicado: (2018) -
Farnesysltransferase Inhibitor Prevents Burn Injury-Induced Metabolome Changes in Muscle
por: Nakazawa, Harumasa, et al.
Publicado: (2022)