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A Critical Role for CRM1 in Regulating HOXA Gene Transcription in CALM-AF10 Leukemias

The leukemogenic CALM-AF10 fusion protein is found in patients with immature acute myeloid and T-lymphoid malignancies. CALM-AF10 leukemias display abnormal H3K79 methylation and increased HOXA cluster gene transcription. Elevated expression of HOXA genes is critical for leukemia maintenance and pro...

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Detalles Bibliográficos
Autores principales:	Conway, Amanda E., Haldeman, Jonathan M., Wechsler, Daniel S., Lavau, Catherine P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297268/ https://www.ncbi.nlm.nih.gov/pubmed/25027513 http://dx.doi.org/10.1038/leu.2014.221

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