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Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood Malaria

The PfEMP1 family of surface proteins is central for Plasmodium falciparum virulence and must retain the ability to bind to host receptors while also diversifying to aid immune evasion. The interaction between CIDRα1 domains of PfEMP1 and endothelial protein C receptor (EPCR) is associated with seve...

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Detalles Bibliográficos
Autores principales:	Lau, Clinton K.Y., Turner, Louise, Jespersen, Jakob S., Lowe, Edward D., Petersen, Bent, Wang, Christian W., Petersen, Jens E.V., Lusingu, John, Theander, Thor G., Lavstsen, Thomas, Higgins, Matthew K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297295/ https://www.ncbi.nlm.nih.gov/pubmed/25482433 http://dx.doi.org/10.1016/j.chom.2014.11.007

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