Different binding motifs of the celiac disease-associated HLA molecules DQ2.5, DQ2.2, and DQ7.5 revealed by relative quantitative proteomics of endogenous peptide repertoires

Celiac disease is caused by intolerance to cereal gluten proteins, and HLA-DQ molecules are involved in the disease pathogenesis by presentation of gluten peptides to CD4(+) T cells. The α- or β-chain sharing HLA molecules DQ2.5, DQ2.2, and DQ7.5 display different risks for the disease. It was recen...

Descripción completa

Detalles Bibliográficos
Autores principales: Bergseng, Elin, Dørum, Siri, Arntzen, Magnus Ø., Nielsen, Morten, Nygård, Ståle, Buus, Søren, de Souza, Gustavo A., Sollid, Ludvig M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297300/
https://www.ncbi.nlm.nih.gov/pubmed/25502872
http://dx.doi.org/10.1007/s00251-014-0819-9

Ejemplares similares

Ejemplares similares