Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke

The immune system response and inflammation play a key role in brain injury during and after a stroke. The acute immune response is responsible for secondary brain tissue damage immediately after the stroke, followed by immunosuppression due to sympathetic nervous system activation. The latter incre...

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Detalles Bibliográficos
Autores principales: Winklewski, Pawel J, Radkowski, Marek, Demkow, Urszula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297381/
https://www.ncbi.nlm.nih.gov/pubmed/25539803
http://dx.doi.org/10.1186/s12974-014-0213-4
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author Winklewski, Pawel J
Radkowski, Marek
Demkow, Urszula
author_facet Winklewski, Pawel J
Radkowski, Marek
Demkow, Urszula
author_sort Winklewski, Pawel J
collection PubMed
description The immune system response and inflammation play a key role in brain injury during and after a stroke. The acute immune response is responsible for secondary brain tissue damage immediately after the stroke, followed by immunosuppression due to sympathetic nervous system activation. The latter increases risk of infection complications, such as pneumonia. The pneumonia-related inflammatory state can release a bystander autoimmune response against central nervous system antigens, thereby initiating a vicious circle. The aim of this review is to summarize the relationship between ischemic stroke, sympathetic nervous system activation and pulmonary infection.
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spelling pubmed-42973812015-01-18 Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke Winklewski, Pawel J Radkowski, Marek Demkow, Urszula J Neuroinflammation Review The immune system response and inflammation play a key role in brain injury during and after a stroke. The acute immune response is responsible for secondary brain tissue damage immediately after the stroke, followed by immunosuppression due to sympathetic nervous system activation. The latter increases risk of infection complications, such as pneumonia. The pneumonia-related inflammatory state can release a bystander autoimmune response against central nervous system antigens, thereby initiating a vicious circle. The aim of this review is to summarize the relationship between ischemic stroke, sympathetic nervous system activation and pulmonary infection. BioMed Central 2014-12-24 /pmc/articles/PMC4297381/ /pubmed/25539803 http://dx.doi.org/10.1186/s12974-014-0213-4 Text en © Winklewski et al.; licensee BioMed Central. 2014 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Winklewski, Pawel J
Radkowski, Marek
Demkow, Urszula
Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke
title Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke
title_full Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke
title_fullStr Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke
title_full_unstemmed Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke
title_short Cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke
title_sort cross-talk between the inflammatory response, sympathetic activation and pulmonary infection in the ischemic stroke
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297381/
https://www.ncbi.nlm.nih.gov/pubmed/25539803
http://dx.doi.org/10.1186/s12974-014-0213-4
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