Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a primary progressive neurodegenerative disease characterised by neuronal loss of lower motor neurons (in the spinal cord and brainstem) and/or upper motor neurons (in the motor cortex) and subsequent denervation atrophy of skeletal muscle. AIM: A c...

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Detalles Bibliográficos
Autores principales: Al-Sarraj, Safa, King, Andrew, Cleveland, Matt, Pradat, Pierre-François, Corse, Andrea, Rothstein, Jeffrey D, Leigh, Peter Nigel, Abila, Bams, Bates, Stewart, Wurthner, Jens, Meininger, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297389/
https://www.ncbi.nlm.nih.gov/pubmed/25510661
http://dx.doi.org/10.1186/s40478-014-0165-z

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