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Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a primary progressive neurodegenerative disease characterised by neuronal loss of lower motor neurons (in the spinal cord and brainstem) and/or upper motor neurons (in the motor cortex) and subsequent denervation atrophy of skeletal muscle. AIM: A c...
Autores principales: | Al-Sarraj, Safa, King, Andrew, Cleveland, Matt, Pradat, Pierre-François, Corse, Andrea, Rothstein, Jeffrey D, Leigh, Peter Nigel, Abila, Bams, Bates, Stewart, Wurthner, Jens, Meininger, Vincent |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297389/ https://www.ncbi.nlm.nih.gov/pubmed/25510661 http://dx.doi.org/10.1186/s40478-014-0165-z |
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