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Lycopene as A Carotenoid Provides Radioprotectant and Antioxidant Effects by Quenching Radiation-Induced Free Radical Singlet Oxygen: An Overview
Radio-protectors are agents that protect human cells and tissues from undesirable effects of ionizing radiation by mainly scavenging radiation-induced free radicals. Although chemical radio-protectors diminish these deleterious side effects they induce a number of unwanted effects on humans such as...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royan Institute
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297477/ https://www.ncbi.nlm.nih.gov/pubmed/25685729 |
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author | Pirayesh Islamian, Jalil Mehrali, Habib |
author_facet | Pirayesh Islamian, Jalil Mehrali, Habib |
author_sort | Pirayesh Islamian, Jalil |
collection | PubMed |
description | Radio-protectors are agents that protect human cells and tissues from undesirable effects of ionizing radiation by mainly scavenging radiation-induced free radicals. Although chemical radio-protectors diminish these deleterious side effects they induce a number of unwanted effects on humans such as blood pressure modifications, vomiting, nausea, and both local and generalized cutaneous reactions. These disadvantages have led to emphasis on the use of some botanical radio-protectants as alternatives. This review has collected and organized studies on a plant-derived radio-protector, lycopene. Lycopene protects normal tissues and cells by scavenging free radicals. Therefore, treatment of cells with lycopene prior to exposure to an oxidative stress, oxidative molecules or ionizing radiation may be an effective approach in diminishing undesirable effects of radiation byproducts. Studies have designated lycopene to be an effective radio-protector with negligible side effects. |
format | Online Article Text |
id | pubmed-4297477 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Royan Institute |
record_format | MEDLINE/PubMed |
spelling | pubmed-42974772015-02-13 Lycopene as A Carotenoid Provides Radioprotectant and Antioxidant Effects by Quenching Radiation-Induced Free Radical Singlet Oxygen: An Overview Pirayesh Islamian, Jalil Mehrali, Habib Cell J Review Article Radio-protectors are agents that protect human cells and tissues from undesirable effects of ionizing radiation by mainly scavenging radiation-induced free radicals. Although chemical radio-protectors diminish these deleterious side effects they induce a number of unwanted effects on humans such as blood pressure modifications, vomiting, nausea, and both local and generalized cutaneous reactions. These disadvantages have led to emphasis on the use of some botanical radio-protectants as alternatives. This review has collected and organized studies on a plant-derived radio-protector, lycopene. Lycopene protects normal tissues and cells by scavenging free radicals. Therefore, treatment of cells with lycopene prior to exposure to an oxidative stress, oxidative molecules or ionizing radiation may be an effective approach in diminishing undesirable effects of radiation byproducts. Studies have designated lycopene to be an effective radio-protector with negligible side effects. Royan Institute 2015 2015-01-13 /pmc/articles/PMC4297477/ /pubmed/25685729 Text en Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Pirayesh Islamian, Jalil Mehrali, Habib Lycopene as A Carotenoid Provides Radioprotectant and Antioxidant Effects by Quenching Radiation-Induced Free Radical Singlet Oxygen: An Overview |
title | Lycopene as A Carotenoid Provides Radioprotectant and
Antioxidant Effects by Quenching Radiation-Induced
Free Radical Singlet Oxygen: An Overview |
title_full | Lycopene as A Carotenoid Provides Radioprotectant and
Antioxidant Effects by Quenching Radiation-Induced
Free Radical Singlet Oxygen: An Overview |
title_fullStr | Lycopene as A Carotenoid Provides Radioprotectant and
Antioxidant Effects by Quenching Radiation-Induced
Free Radical Singlet Oxygen: An Overview |
title_full_unstemmed | Lycopene as A Carotenoid Provides Radioprotectant and
Antioxidant Effects by Quenching Radiation-Induced
Free Radical Singlet Oxygen: An Overview |
title_short | Lycopene as A Carotenoid Provides Radioprotectant and
Antioxidant Effects by Quenching Radiation-Induced
Free Radical Singlet Oxygen: An Overview |
title_sort | lycopene as a carotenoid provides radioprotectant and
antioxidant effects by quenching radiation-induced
free radical singlet oxygen: an overview |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297477/ https://www.ncbi.nlm.nih.gov/pubmed/25685729 |
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