Cargando…
IL-25-responsive, lineage-negative KLRG1(hi) cells are multipotential “inflammatory” type 2 innate lymphoid cells
Innate lymphoid cells (ILCs) are lymphocyte-like cells lacking T or B cell receptors that mediate protective and repair functions through cytokine secretion. Among them, type 2 ILC (ILC2) cells are capable of producing type 2 cytokines. We report the existence of an inflammatory (i) ILC2 population...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297567/ https://www.ncbi.nlm.nih.gov/pubmed/25531830 http://dx.doi.org/10.1038/ni.3078 |
Sumario: | Innate lymphoid cells (ILCs) are lymphocyte-like cells lacking T or B cell receptors that mediate protective and repair functions through cytokine secretion. Among them, type 2 ILC (ILC2) cells are capable of producing type 2 cytokines. We report the existence of an inflammatory (i) ILC2 population responsive to IL-25 that complements IL-33-responsive natural (n) ILC2 cells. iILC2 cells developed into nILC2-like cells in vitro and in vivo, contributing to expulsion of Nippostrongylus brasiliensis. They also acquired IL-17-producing capacity, providing partial protection against Candida albicans. We propose that iILC2 cells are transient ILC progenitors mobilized by inflammation and infection that develop into nILC2-like cells or ILC3-like cells and contribute to immunity to both helminths and fungi. |
---|