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Regulatory T cells require the phosphatase PTEN to restrain type 1 and follicular helper T-cell responses

The interplay between effector and regulatory T (T(reg)) cells is crucial for adaptive immunity, but how T(reg) control diverse effector responses is elusive. We found that the phosphatase PTEN links T(reg) stability to repression of T(H)1 and T(FH) (follicular helper) responses. Depletion of PTEN i...

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Detalles Bibliográficos
Autores principales:	Shrestha, Sharad, Yang, Kai, Guy, Cliff, Vogel, Peter, Neale, Geoffrey, Chi, Hongbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297581/ https://www.ncbi.nlm.nih.gov/pubmed/25559258 http://dx.doi.org/10.1038/ni.3076

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