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ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells

Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeophyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigmentation is not fully understood. This study investigated the effect...

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Autores principales: Song, Yu Seok, Balcos, Marie Carmel, Yun, Hye-Young, Baek, Kwang Jin, Kwon, Nyoun Soo, Kim, Myo-Kyoung, Kim, Dong-Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Physiological Society and The Korean Society of Pharmacology 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297759/
https://www.ncbi.nlm.nih.gov/pubmed/25605994
http://dx.doi.org/10.4196/kjpp.2015.19.1.29
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author Song, Yu Seok
Balcos, Marie Carmel
Yun, Hye-Young
Baek, Kwang Jin
Kwon, Nyoun Soo
Kim, Myo-Kyoung
Kim, Dong-Seok
author_facet Song, Yu Seok
Balcos, Marie Carmel
Yun, Hye-Young
Baek, Kwang Jin
Kwon, Nyoun Soo
Kim, Myo-Kyoung
Kim, Dong-Seok
author_sort Song, Yu Seok
collection PubMed
description Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeophyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigmentation is not fully understood. This study investigated the effects of fucoidan on melanogenesis and related signaling pathways using Mel-Ab cells. Fucoidan significantly decreased melanin content. While fucoidan treatment decreased tyrosinase activity, it did not do so directly. Western blot analysis indicated that fucoidan downregulated microphthalmia-associated transcription factor and reduced tyrosinase protein expression. Further investigation showed that fucoidan activated the extracellular signal-regulated kinase (ERK) pathway, suggesting a possible mechanism for the inhibition of melanin synthesis. Treatment with PD98059, a specific ERK inhibitor, resulted in the recovery of melanin production. Taken together, these findings suggest that fucoidan inhibits melanogenesis via ERK phosphorylation.
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spelling pubmed-42977592015-01-20 ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells Song, Yu Seok Balcos, Marie Carmel Yun, Hye-Young Baek, Kwang Jin Kwon, Nyoun Soo Kim, Myo-Kyoung Kim, Dong-Seok Korean J Physiol Pharmacol Original Article Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeophyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigmentation is not fully understood. This study investigated the effects of fucoidan on melanogenesis and related signaling pathways using Mel-Ab cells. Fucoidan significantly decreased melanin content. While fucoidan treatment decreased tyrosinase activity, it did not do so directly. Western blot analysis indicated that fucoidan downregulated microphthalmia-associated transcription factor and reduced tyrosinase protein expression. Further investigation showed that fucoidan activated the extracellular signal-regulated kinase (ERK) pathway, suggesting a possible mechanism for the inhibition of melanin synthesis. Treatment with PD98059, a specific ERK inhibitor, resulted in the recovery of melanin production. Taken together, these findings suggest that fucoidan inhibits melanogenesis via ERK phosphorylation. The Korean Physiological Society and The Korean Society of Pharmacology 2015-01 2014-12-31 /pmc/articles/PMC4297759/ /pubmed/25605994 http://dx.doi.org/10.4196/kjpp.2015.19.1.29 Text en Copyright © 2015 The Korean Physiological Society and The Korean Society of Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Song, Yu Seok
Balcos, Marie Carmel
Yun, Hye-Young
Baek, Kwang Jin
Kwon, Nyoun Soo
Kim, Myo-Kyoung
Kim, Dong-Seok
ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
title ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
title_full ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
title_fullStr ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
title_full_unstemmed ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
title_short ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
title_sort erk activation by fucoidan leads to inhibition of melanogenesis in mel-ab cells
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297759/
https://www.ncbi.nlm.nih.gov/pubmed/25605994
http://dx.doi.org/10.4196/kjpp.2015.19.1.29
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