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ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells
Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeophyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigmentation is not fully understood. This study investigated the effect...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Physiological Society and The Korean Society of Pharmacology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297759/ https://www.ncbi.nlm.nih.gov/pubmed/25605994 http://dx.doi.org/10.4196/kjpp.2015.19.1.29 |
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author | Song, Yu Seok Balcos, Marie Carmel Yun, Hye-Young Baek, Kwang Jin Kwon, Nyoun Soo Kim, Myo-Kyoung Kim, Dong-Seok |
author_facet | Song, Yu Seok Balcos, Marie Carmel Yun, Hye-Young Baek, Kwang Jin Kwon, Nyoun Soo Kim, Myo-Kyoung Kim, Dong-Seok |
author_sort | Song, Yu Seok |
collection | PubMed |
description | Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeophyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigmentation is not fully understood. This study investigated the effects of fucoidan on melanogenesis and related signaling pathways using Mel-Ab cells. Fucoidan significantly decreased melanin content. While fucoidan treatment decreased tyrosinase activity, it did not do so directly. Western blot analysis indicated that fucoidan downregulated microphthalmia-associated transcription factor and reduced tyrosinase protein expression. Further investigation showed that fucoidan activated the extracellular signal-regulated kinase (ERK) pathway, suggesting a possible mechanism for the inhibition of melanin synthesis. Treatment with PD98059, a specific ERK inhibitor, resulted in the recovery of melanin production. Taken together, these findings suggest that fucoidan inhibits melanogenesis via ERK phosphorylation. |
format | Online Article Text |
id | pubmed-4297759 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Physiological Society and The Korean Society of Pharmacology |
record_format | MEDLINE/PubMed |
spelling | pubmed-42977592015-01-20 ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells Song, Yu Seok Balcos, Marie Carmel Yun, Hye-Young Baek, Kwang Jin Kwon, Nyoun Soo Kim, Myo-Kyoung Kim, Dong-Seok Korean J Physiol Pharmacol Original Article Fucoidan, a fucose-rich sulfated polysaccharide derived from brown seaweed in the class Phaeophyceae, has been widely studied for its possible health benefits. However, the potential of fucoidan as a possible treatment for hyperpigmentation is not fully understood. This study investigated the effects of fucoidan on melanogenesis and related signaling pathways using Mel-Ab cells. Fucoidan significantly decreased melanin content. While fucoidan treatment decreased tyrosinase activity, it did not do so directly. Western blot analysis indicated that fucoidan downregulated microphthalmia-associated transcription factor and reduced tyrosinase protein expression. Further investigation showed that fucoidan activated the extracellular signal-regulated kinase (ERK) pathway, suggesting a possible mechanism for the inhibition of melanin synthesis. Treatment with PD98059, a specific ERK inhibitor, resulted in the recovery of melanin production. Taken together, these findings suggest that fucoidan inhibits melanogenesis via ERK phosphorylation. The Korean Physiological Society and The Korean Society of Pharmacology 2015-01 2014-12-31 /pmc/articles/PMC4297759/ /pubmed/25605994 http://dx.doi.org/10.4196/kjpp.2015.19.1.29 Text en Copyright © 2015 The Korean Physiological Society and The Korean Society of Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Song, Yu Seok Balcos, Marie Carmel Yun, Hye-Young Baek, Kwang Jin Kwon, Nyoun Soo Kim, Myo-Kyoung Kim, Dong-Seok ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells |
title | ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells |
title_full | ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells |
title_fullStr | ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells |
title_full_unstemmed | ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells |
title_short | ERK Activation by Fucoidan Leads to Inhibition of Melanogenesis in Mel-Ab Cells |
title_sort | erk activation by fucoidan leads to inhibition of melanogenesis in mel-ab cells |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297759/ https://www.ncbi.nlm.nih.gov/pubmed/25605994 http://dx.doi.org/10.4196/kjpp.2015.19.1.29 |
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