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Restoration of Progranulin Expression Rescues Cortical Neuron Generation in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia

To understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FTD), we created induced pluripotent stem cells (iPSCs) from patients carrying the GRN(IVS1+5G > C) mutation (FTD-iPSCs). FTD-iPSCs were fated to cortical neurons, the cells most affected in FTD. Although g...

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Detalles Bibliográficos
Autores principales:	Raitano, Susanna, Ordovàs, Laura, De Muynck, Louis, Guo, Wenting, Espuny-Camacho, Ira, Geraerts, Martine, Khurana, Satish, Vanuytsel, Kim, Tóth, Balazs I., Voets, Thomas, Vandenberghe, Rik, Cathomen, Toni, Van Den Bosch, Ludo, Vanderhaeghen, Pierre, Van Damme, Philip, Verfaillie, Catherine M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2014
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297877/ https://www.ncbi.nlm.nih.gov/pubmed/25556567 http://dx.doi.org/10.1016/j.stemcr.2014.12.001

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