Cargando…
Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction
The cytochrome P450 mixed function oxidase enzymes are the major catalysts involved in drug metabolism. There are many forms of P450. CYP2E1 metabolizes many toxicologically important compounds including ethanol and is active in generating reactive oxygen species. Since several of the contributions...
Autor principal: | Cederbaum, Arthur I. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297943/ https://www.ncbi.nlm.nih.gov/pubmed/25454746 http://dx.doi.org/10.1016/j.redox.2014.09.007 |
Ejemplares similares
-
Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications
por: Cederbaum, Arthur I.
Publicado: (2014) -
Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity
por: Lu, Yongke, et al.
Publicado: (2015) -
Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK()
por: Wu, Defeng, et al.
Publicado: (2013) -
CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases
por: Cederbaum, Arthur I., et al.
Publicado: (2012) -
HBx Inhibits CYP2E1 Gene Expression via Downregulating HNF4α in Human Hepatoma Cells
por: Liu, Hongming, et al.
Publicado: (2014)