The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation

Here, we review the role of oxidative protein modification as a signal for recognition and degradation of proteins. It was clearly demonstrated that the ATP- and ubiquitin-independent 20S proteasome is playing a key role in the selective removal of oxidized proteins. Furthermore, the current knowled...

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Detalles Bibliográficos
Autores principales: Jung, Tobias, Höhn, Annika, Grune, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297946/
https://www.ncbi.nlm.nih.gov/pubmed/25460724
http://dx.doi.org/10.1016/j.redox.2013.12.008
Descripción
Sumario:Here, we review the role of oxidative protein modification as a signal for recognition and degradation of proteins. It was clearly demonstrated that the ATP- and ubiquitin-independent 20S proteasome is playing a key role in the selective removal of oxidized proteins. Furthermore, the current knowledge of the substrate susceptibility on the degradation of oxidized proteins and the role of the immunoproteasome will be highlighted.

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