The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation

Here, we review the role of oxidative protein modification as a signal for recognition and degradation of proteins. It was clearly demonstrated that the ATP- and ubiquitin-independent 20S proteasome is playing a key role in the selective removal of oxidized proteins. Furthermore, the current knowled...

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Detalles Bibliográficos
Autores principales: Jung, Tobias, Höhn, Annika, Grune, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297946/
https://www.ncbi.nlm.nih.gov/pubmed/25460724
http://dx.doi.org/10.1016/j.redox.2013.12.008
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author Jung, Tobias
Höhn, Annika
Grune, Tilman
author_facet Jung, Tobias
Höhn, Annika
Grune, Tilman
author_sort Jung, Tobias
collection PubMed
description Here, we review the role of oxidative protein modification as a signal for recognition and degradation of proteins. It was clearly demonstrated that the ATP- and ubiquitin-independent 20S proteasome is playing a key role in the selective removal of oxidized proteins. Furthermore, the current knowledge of the substrate susceptibility on the degradation of oxidized proteins and the role of the immunoproteasome will be highlighted.
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spelling pubmed-42979462015-01-21 The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation Jung, Tobias Höhn, Annika Grune, Tilman Redox Biol Review Article Here, we review the role of oxidative protein modification as a signal for recognition and degradation of proteins. It was clearly demonstrated that the ATP- and ubiquitin-independent 20S proteasome is playing a key role in the selective removal of oxidized proteins. Furthermore, the current knowledge of the substrate susceptibility on the degradation of oxidized proteins and the role of the immunoproteasome will be highlighted. Elsevier 2013-12-17 /pmc/articles/PMC4297946/ /pubmed/25460724 http://dx.doi.org/10.1016/j.redox.2013.12.008 Text en © 2013 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Review Article
Jung, Tobias
Höhn, Annika
Grune, Tilman
The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
title The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
title_full The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
title_fullStr The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
title_full_unstemmed The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
title_short The proteasome and the degradation of oxidized proteins: Part II – protein oxidation and proteasomal degradation
title_sort proteasome and the degradation of oxidized proteins: part ii – protein oxidation and proteasomal degradation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297946/
https://www.ncbi.nlm.nih.gov/pubmed/25460724
http://dx.doi.org/10.1016/j.redox.2013.12.008
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