Cargando…

Epigenetic modification of the PD-1 (Pdcd1) promoter in effector CD4(+) T cells tolerized by peptide immunotherapy

Clinically effective antigen-based immunotherapy must silence antigen-experienced effector T cells (Teff) driving ongoing immune pathology. Using CD4(+) autoimmune Teff cells, we demonstrate that peptide immunotherapy (PIT) is strictly dependent upon sustained T cell expression of the co-inhibitory...

Descripción completa

Detalles Bibliográficos
Autores principales:	McPherson, Rhoanne C, Konkel, Joanne E, Prendergast, Catriona T, Thomson, John P, Ottaviano, Raffaele, Leech, Melanie D, Kay, Oliver, Zandee, Stephanie E J, Sweenie, Claire H, Wraith, David C, Meehan, Richard R, Drake, Amanda J, Anderton, Stephen M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297948/ https://www.ncbi.nlm.nih.gov/pubmed/25546306 http://dx.doi.org/10.7554/eLife.03416

Ejemplares similares

A Context-Dependent Role for αv Integrins in Regulatory T Cell Accumulation at Sites of Inflammation
por: Mair, Iris, et al.
Publicado: (2018)

Rapid reprogramming of epigenetic and transcriptional profiles in mammalian culture systems
por: Nestor, Colm E, et al.
Publicado: (2015)

PD‐1 expression is upregulated on adapted T cells in experimental autoimmune encephalomyelitis but is not required to maintain a hyporesponsive state
por: Mair, Iris, et al.
Publicado: (2018)

Exposure to inflammatory cytokines selectively limits GM-CSF production by induced T regulatory cells
por: Reynolds, Ben C, et al.
Publicado: (2014)

T-bet Expression by Foxp3(+) T Regulatory Cells is Not Essential for Their Suppressive Function in CNS Autoimmune Disease or Colitis
por: McPherson, Rhoanne C., et al.
Publicado: (2015)

Identification of PDCD1 and PDCD1LG2 as Prognostic Biomarkers and Associated with Immune Infiltration in Hepatocellular Carcinoma
por: Li, Wang, et al.
Publicado: (2022)

Upregulated PD-1 Expression Is Associated with the Development of Systemic Lupus Erythematosus, but Not the PD-1.1 Allele of the PDCD1 Gene
por: Jiao, Qingqing, et al.
Publicado: (2014)

Relationship of PD-1 (PDCD1) and PD-L1 (CD274) Single Nucleotide Polymorphisms with Polycystic Ovary Syndrome
por: Han, Rui, et al.
Publicado: (2021)

PDCD1 Polymorphisms May Predict Response to Anti-PD-1 Blockade in Patients With Metastatic Melanoma
por: Parakh, Sagun, et al.
Publicado: (2021)

PDCD1 (PD-1) promoter methylation predicts outcome in head and neck squamous cell carcinoma patients
por: Goltz, Diane, et al.
Publicado: (2017)

Non-alcoholic fatty liver disease (NAFLD) is associated with dynamic changes in DNA hydroxymethylation
por: Lyall, Marcus J., et al.
Publicado: (2019)

A PDCD1 Role in the Genetic Predisposition to NAFLD-HCC?
por: Eldafashi, Nardeen, et al.
Publicado: (2021)

Germline Variation in PDCD1 Is Associated with Overall Survival in Patients with Metastatic Melanoma Treated with Anti-PD-1 Monotherapy
por: de With, Mirjam, et al.
Publicado: (2021)

Hyperprogressive Disease during Anti-PD-1 (PDCD1) / PD-L1 (CD274) Therapy: A Systematic Review and Meta-Analysis
por: Kim, Jong Yeob, et al.
Publicado: (2019)

Prognostic value of CD8 + PD-1+ immune infiltrates and PDCD1 gene expression in triple negative breast cancer
por: Yeong, Joe, et al.
Publicado: (2019)

Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
por: Elomaa, Hanna, et al.
Publicado: (2023)

Recombinant human PDCD5 (rhPDCD5) protein is protective in a mouse model of multiple sclerosis
por: Xiao, Juan, et al.
Publicado: (2015)

Conditional Deletion of Pdcd1 Identifies the Cell-Intrinsic Action of PD-1 on Functional CD8 T Cell Subsets for Antitumor Efficacy
por: Raghavan, Sukanya, et al.
Publicado: (2021)

Association between PDCD1 gene polymorphisms and psoriasis susceptibility in the Chinese population
por: Hua, Shengyuan, et al.
Publicado: (2021)

WWP2 ameliorates oxidative stress and inflammation in atherosclerotic mice through regulation of PDCD4/HO-1 pathway: WWP2 interacted with PDCD4 ameliorates AS
por: Wang, Xingye, et al.
Publicado: (2022)

PDCD1 (PD-1) is a direct target of miR-15a-5p and miR-16-5p
por: Palamarchuk, Alexey, et al.
Publicado: (2022)

Translation, Pdcd4 and eIF4A
por: Biyanee, Abhiruchi, et al.
Publicado: (2015)

The multifaceted PDCD10/CCM3 gene
por: Valentino, Mariaelena, et al.
Publicado: (2020)

Dissecting the Roles of PDCD4 in Breast Cancer
por: Cai, Qian, et al.
Publicado: (2022)

Defining baseline epigenetic landscapes in the rat liver
por: Thomson, John P, et al.
Publicado: (2017)

Anti-Inflammatory Effects of Recombinant Human PDCD5 (rhPDCD5) in a Rat Collagen-Induced Model of Arthritis
por: Xiao, Juan, et al.
Publicado: (2014)

Molecular Characterisation and Functions of Fis1 and PDCD6 Genes from Echinococcus granulosus
por: Wang, Ning, et al.
Publicado: (2018)

Association of the programmed cell death 1 (PDCD1) gene polymorphism with ankylosing spondylitis in the Korean population
por: Lee, Sang-Hoon, et al.
Publicado: (2006)

Increased PD-1 Level in Severe Cervical Injury Is Associated With the Rare Programmed Cell Death 1 (PDCD1) rs36084323 A Allele in a Dominant Model
por: da Silva, Mauro César, et al.
Publicado: (2021)

PD-1 (PDCD1) Promoter Methylation Is a Prognostic Factor in Patients With Diffuse Lower-Grade Gliomas Harboring Isocitrate Dehydrogenase (IDH) Mutations
por: Röver, Lea Kristin, et al.
Publicado: (2018)

An evolutionarily conserved interaction of tumor suppressor protein Pdcd4 with the poly(A)-binding protein contributes to translation suppression by Pdcd4
por: Fehler, Olesja, et al.
Publicado: (2014)

MicroRNA-21 Down-regulates Rb1 Expression by Targeting PDCD4 in Retinoblastoma
por: Shen, Fengmei, et al.
Publicado: (2014)

Tumor suppressor Pdcd4attenuates Sin1 translation to inhibit invasion in colon carcinoma
por: Wang, Qing, et al.
Publicado: (2017)

Case-control Association Study of Autoimmunity Associated Variants in PDCD1 and Juvenile Idiopathic Arthritis
por: Tejeda, Christina, et al.
Publicado: (2017)

Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy
por: Manirujjaman, M., et al.
Publicado: (2020)

Evaluation of the possible association of PDCD-1 and LAG3 gene polymorphisms with hepatocellular carcinoma risk
por: Wei, Jiankai, et al.
Publicado: (2023)

The role of tumour suppressor PDCD4 in beta cell death in hypoxia
por: Kumar, Sandeep, et al.
Publicado: (2017)

PD-L1 (CD274) and PD-L2 (PDCD1LG2) promoter methylation is associated with HPV infection and transcriptional repression in head and neck squamous cell carcinomas
por: Franzen, Alina, et al.
Publicado: (2017)

A novel non-viral PDCD1 site-integrated CAR design: killing 2 birds with 1 stone
por: Cui, Yuanbin, et al.
Publicado: (2022)

The Campylobacter jejuni CiaD effector co-opts the host cell protein IQGAP1 to promote cell entry
por: Negretti, Nicholas M., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1jr6tl2fdmd8c5pphb6vu7mmmd