Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors

BACKGROUND: Itch-producing compounds stimulate receptors expressed on small diameter fibers that innervate the skin. Many of the currently known pruritogen receptors are G(q) Protein-Coupled Receptors (G(q)PCR), which activate Protein Kinase C (PKC). Specific isoforms of PKC have been previously sho...

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Detalles Bibliográficos
Autores principales: Valtcheva, Manouela V, Davidson, Steve, Zhao, Chengshui, Leitges, Michael, Gereau, Robert W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298070/
https://www.ncbi.nlm.nih.gov/pubmed/25558916
http://dx.doi.org/10.1186/1744-8069-11-1

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