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Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen

INTRODUCTION: Members of the peptidylarginine deiminase (PAD) family catalyse the posttranslational conversion of peptidylarginine to peptidylcitrulline. Citrullination of proteins is well described in rheumatoid arthritis (RA), and hypercitrullination of proteins may be related to inflammation in g...

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Detalles Bibliográficos
Autores principales:	Damgaard, Dres, Senolt, Ladislav, Nielsen, Michael Friberg, Pruijn, Ger J, Nielsen, Claus H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298085/ https://www.ncbi.nlm.nih.gov/pubmed/25475141 http://dx.doi.org/10.1186/s13075-014-0498-9

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