IKKα negatively regulates ASC-dependent inflammasome activation

The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines. Here we report that IKKα is a critical negative regulator of ASC-dependent inflammasomes. IKKα controls the inflammasome at the level o...

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Detalles Bibliográficos
Autores principales: Martin, Bradley N., Wang, Chenhui, Willette-Brown, Jami, Herjan, Tomasz, Gulen, Muhammet F., Zhou, Hao, Bulek, Katarzyna, Franchi, Luigi, Sato, Takashi, Narla, Goutham, Zhong, Xiao-Ping, Thomas, James, Klinman, Dennis, Fitzgerald, Katherine A., Karin, Michael, Nuñez, Gabriel, Dubyak, George, Hu, Yinling, Li, Xiaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298287/
https://www.ncbi.nlm.nih.gov/pubmed/25266676
http://dx.doi.org/10.1038/ncomms5977

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