Lower irritation microemulsion-based rotigotine gel: formulation optimization and in vitro and in vivo studies

BACKGROUND: Rotigotine is a potent and selective D(1), D(2), and D(3) dopaminergic receptor agonist. Due to an extensive first-pass effect, it has a very low oral bioavailability (approximately 0.5% in rats). PURPOSE: The present investigation aimed to develop a microemulsion-based hydrogel for tran...

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Detalles Bibliográficos
Autores principales: Wang, Zheng, Mu, Hong-Jie, Zhang, Xue-Mei, Ma, Peng-Kai, Lian, Sheng-Nan, Zhang, Feng-Pu, Chu, Sheng-Ying, Zhang, Wen-Wen, Wang, Ai-Ping, Wang, Wen-Yan, Sun, Kao-Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298334/
https://www.ncbi.nlm.nih.gov/pubmed/25609965
http://dx.doi.org/10.2147/IJN.S74079

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