Inhibition of mitotic Aurora kinase A by alisertib induces apoptosis and autophagy of human gastric cancer AGS and NCI-N78 cells

Gastric cancer is one of the most common cancers and responds poorly to current chemotherapy. Alisertib (ALS) is a second-generation, orally bioavailable, highly selective small-molecule inhibitor of the serine/threonine protein kinase Aurora kinase A (AURKA). ALS has been shown to have potent antic...

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Detalles Bibliográficos
Autores principales: Yuan, Chun-Xiu, Zhou, Zhi-Wei, Yang, Yin-Xue, He, Zhi-Xu, Zhang, Xueji, Wang, Dong, Yang, Tianxing, Wang, Ning-Ju, Zhao, Ruan Jin, Zhou, Shu-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298344/
https://www.ncbi.nlm.nih.gov/pubmed/25609923
http://dx.doi.org/10.2147/DDDT.S74127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298344/
https://www.ncbi.nlm.nih.gov/pubmed/25609923
http://dx.doi.org/10.2147/DDDT.S74127

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