Sustained in vivo signaling by long-lived IL-2 induces prolonged increases of regulatory T cells

Regulatory T cells (Tregs) expressing FOXP3 are essential for the maintenance of self-tolerance and are deficient in many common autoimmune diseases. Immune tolerance is maintained in part by IL-2 and deficiencies in the IL-2 pathway cause reduced Treg function and an increased risk of autoimmunity....

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Detalles Bibliográficos
Autores principales: Bell, Charles J.M., Sun, Yongliang, Nowak, Urszula M., Clark, Jan, Howlett, Sarah, Pekalski, Marcin L., Yang, Xin, Ast, Oliver, Waldhauer, Inja, Freimoser-Grundschober, Anne, Moessner, Ekkehard, Umana, Pablo, Klein, Christian, Hosse, Ralf J., Wicker, Linda S., Peterson, Laurence B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298360/
https://www.ncbi.nlm.nih.gov/pubmed/25457307
http://dx.doi.org/10.1016/j.jaut.2014.10.002

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