Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging

During aging, progressive deleterious changes increase the risk of disease and death. Prominent molecular hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, cellular senescence, stem cell exhaustion, and altered intercellular communication....

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Autores principales: Grammatikakis, Ioannis, Panda, Amaresh C., Abdelmohsen, Kotb, Gorospe, Myriam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298369/
https://www.ncbi.nlm.nih.gov/pubmed/25543668
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author Grammatikakis, Ioannis
Panda, Amaresh C.
Abdelmohsen, Kotb
Gorospe, Myriam
author_facet Grammatikakis, Ioannis
Panda, Amaresh C.
Abdelmohsen, Kotb
Gorospe, Myriam
author_sort Grammatikakis, Ioannis
collection PubMed
description During aging, progressive deleterious changes increase the risk of disease and death. Prominent molecular hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, cellular senescence, stem cell exhaustion, and altered intercellular communication. Long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes, including age-related diseases like cancer, cardiovascular pathologies, and neurodegenerative disorders. Evidence is emerging that lncRNAs influence the molecular processes that underlie age-associated phenotypes. Here, we review our current understanding of lncRNAs that control the development of aging traits.
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spelling pubmed-42983692015-01-27 Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging Grammatikakis, Ioannis Panda, Amaresh C. Abdelmohsen, Kotb Gorospe, Myriam Aging (Albany NY) Review During aging, progressive deleterious changes increase the risk of disease and death. Prominent molecular hallmarks of aging are genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, cellular senescence, stem cell exhaustion, and altered intercellular communication. Long noncoding RNAs (lncRNAs) play important roles in a wide range of biological processes, including age-related diseases like cancer, cardiovascular pathologies, and neurodegenerative disorders. Evidence is emerging that lncRNAs influence the molecular processes that underlie age-associated phenotypes. Here, we review our current understanding of lncRNAs that control the development of aging traits. Impact Journals LLC 2014-12-22 /pmc/articles/PMC4298369/ /pubmed/25543668 Text en Copyright: © 2014 Grammatikakis et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Review
Grammatikakis, Ioannis
Panda, Amaresh C.
Abdelmohsen, Kotb
Gorospe, Myriam
Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging
title Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging
title_full Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging
title_fullStr Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging
title_full_unstemmed Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging
title_short Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging
title_sort long noncoding rnas (lncrnas) and the molecular hallmarks of aging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298369/
https://www.ncbi.nlm.nih.gov/pubmed/25543668
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