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The impact of genetic heterogeneity on biomarker development in kidney cancer assessed by multiregional sampling

Primary clear cell renal cell carcinoma (ccRCC) genetic heterogeneity may lead to an underestimation of the mutational burden detected from a single site evaluation. We sought to characterize the extent of clonal branching involving key tumor suppressor mutations in primary ccRCC and determine if ge...

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Detalles Bibliográficos
Autores principales:	Sankin, Alexander, Hakimi, Abraham A, Mikkilineni, Nina, Ostrovnaya, Irina, Silk, Mikhail T, Liang, Yupu, Mano, Roy, Chevinsky, Michael, Motzer, Robert J, Solomon, Stephen B, Cheng, Emily H, Durack, Jeremy C, Coleman, Jonathan A, Russo, Paul, Hsieh, James J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Clinical Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298374/ https://www.ncbi.nlm.nih.gov/pubmed/25124064 http://dx.doi.org/10.1002/cam4.293

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