Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer

Poly (ADP) ribose polymerase (PARP) plays a key role in DNA repair and is highly expressed in small cell lung cancer (SCLC). We investigated the therapeutic impact of PARP inhibition in SCLC. In vitro cytotoxicity of veliparib, cisplatin, carboplatin, and etoposide singly and combined was determined...

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Detalles Bibliográficos
Autores principales: Owonikoko, Taofeek K, Zhang, Guojing, Deng, Xingming, Rossi, Michael R, Switchenko, Jeffrey M, Doho, Gregory H, Chen, Zhengjia, Kim, Sungjin, Strychor, Sandy, Christner, Susan M, Beumer, Jan, Li, Chunyang, Yue, Ping, Chen, Alice, Sica, Gabriel L, Ramalingam, Suresh S, Kowalski, Jeanne, Khuri, Fadlo R, Sun, Shi-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298385/
https://www.ncbi.nlm.nih.gov/pubmed/25124282
http://dx.doi.org/10.1002/cam4.317

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