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Checkpoint-dependent RNR induction promotes fork restart after replicative stress

The checkpoint kinase Rad53 is crucial to regulate DNA replication in the presence of replicative stress. Under conditions that interfere with the progression of replication forks, Rad53 prevents Exo1-dependent fork degradation. However, although EXO1 deletion avoids fork degradation in rad53 mutant...

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Detalles Bibliográficos
Autores principales:	Morafraile, Esther C., Diffley, John F. X., Tercero, José Antonio, Segurado, Mónica
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298733/ https://www.ncbi.nlm.nih.gov/pubmed/25601385 http://dx.doi.org/10.1038/srep07886

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