Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans

Mitochondrial protein Nfu1 plays an important role in the assembly of mitochondrial Fe-S clusters and intracellular iron homeostasis in the model yeast Saccharomyces cerevisiae. In this study, we identified the Nfu1 ortholog in the human fungal pathogen Cryptococcus neoformans. Our data showed that...

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Autores principales: Kim, Jeongmi, Park, Minji, Do, Eunsoo, Jung, Won Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Mycology 2014
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298852/
https://www.ncbi.nlm.nih.gov/pubmed/25606020
http://dx.doi.org/10.5941/MYCO.2014.42.4.427
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author Kim, Jeongmi
Park, Minji
Do, Eunsoo
Jung, Won Hee
author_facet Kim, Jeongmi
Park, Minji
Do, Eunsoo
Jung, Won Hee
author_sort Kim, Jeongmi
collection PubMed
description Mitochondrial protein Nfu1 plays an important role in the assembly of mitochondrial Fe-S clusters and intracellular iron homeostasis in the model yeast Saccharomyces cerevisiae. In this study, we identified the Nfu1 ortholog in the human fungal pathogen Cryptococcus neoformans. Our data showed that C. neoformans Nfu1 localized in the mitochondria and influenced homeostasis of essential metals such as iron, copper and manganese. Marked growth defects were observed in the mutant lacking NFU1, which suggests a critical role of Nfu1 in Fe-S cluster biosynthesis and intracellular metal homeostasis in C. neoformans.
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spelling pubmed-42988522015-01-20 Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans Kim, Jeongmi Park, Minji Do, Eunsoo Jung, Won Hee Mycobiology Research Note Mitochondrial protein Nfu1 plays an important role in the assembly of mitochondrial Fe-S clusters and intracellular iron homeostasis in the model yeast Saccharomyces cerevisiae. In this study, we identified the Nfu1 ortholog in the human fungal pathogen Cryptococcus neoformans. Our data showed that C. neoformans Nfu1 localized in the mitochondria and influenced homeostasis of essential metals such as iron, copper and manganese. Marked growth defects were observed in the mutant lacking NFU1, which suggests a critical role of Nfu1 in Fe-S cluster biosynthesis and intracellular metal homeostasis in C. neoformans. The Korean Society of Mycology 2014-12 2014-12-31 /pmc/articles/PMC4298852/ /pubmed/25606020 http://dx.doi.org/10.5941/MYCO.2014.42.4.427 Text en © The Korean Society of Mycology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Note
Kim, Jeongmi
Park, Minji
Do, Eunsoo
Jung, Won Hee
Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans
title Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans
title_full Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans
title_fullStr Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans
title_full_unstemmed Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans
title_short Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans
title_sort mitochondrial protein nfu1 influences homeostasis of essential metals in the human fungal pathogen cryptococcus neoformans
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298852/
https://www.ncbi.nlm.nih.gov/pubmed/25606020
http://dx.doi.org/10.5941/MYCO.2014.42.4.427
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