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Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats☆

Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly. To establish a hyperhomocysteinemic pregnant rat model, 2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of...

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Autores principales: Wang, Jun, Cui, Yan, Ge, Jing, Ma, Meijing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298889/
https://www.ncbi.nlm.nih.gov/pubmed/25624824
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.25.005
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author Wang, Jun
Cui, Yan
Ge, Jing
Ma, Meijing
author_facet Wang, Jun
Cui, Yan
Ge, Jing
Ma, Meijing
author_sort Wang, Jun
collection PubMed
description Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly. To establish a hyperhomocysteinemic pregnant rat model, 2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation. Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction. Results showed that systolic blood pressure, proteinuria/creatinine ratio, and plasma homocysteine levels in the hyperhomocysteinemic pregnant rats increased significantly, and that body weight and brain weight of rat pups significantly decreased. Folic acid supplementation markedly reversed the above-mentioned abnormal changes of hyperhomocysteinemic pregnant rats and rat pups. These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia- induced preeclampsia in pregnant rats without influencing brain development of rat pups.
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spelling pubmed-42988892015-01-26 Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats☆ Wang, Jun Cui, Yan Ge, Jing Ma, Meijing Neural Regen Res Research and Report Article: Brain Injury and Neural Regeneration Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly. To establish a hyperhomocysteinemic pregnant rat model, 2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation. Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction. Results showed that systolic blood pressure, proteinuria/creatinine ratio, and plasma homocysteine levels in the hyperhomocysteinemic pregnant rats increased significantly, and that body weight and brain weight of rat pups significantly decreased. Folic acid supplementation markedly reversed the above-mentioned abnormal changes of hyperhomocysteinemic pregnant rats and rat pups. These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia- induced preeclampsia in pregnant rats without influencing brain development of rat pups. Medknow Publications & Media Pvt Ltd 2012-09-05 /pmc/articles/PMC4298889/ /pubmed/25624824 http://dx.doi.org/10.3969/j.issn.1673-5374.2012.25.005 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research and Report Article: Brain Injury and Neural Regeneration
Wang, Jun
Cui, Yan
Ge, Jing
Ma, Meijing
Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats☆
title Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats☆
title_full Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats☆
title_fullStr Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats☆
title_full_unstemmed Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats☆
title_short Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats☆
title_sort folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats☆
topic Research and Report Article: Brain Injury and Neural Regeneration
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4298889/
https://www.ncbi.nlm.nih.gov/pubmed/25624824
http://dx.doi.org/10.3969/j.issn.1673-5374.2012.25.005
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